Young and old rats have different strategies of metabolic adaptation to Cu-induced liver fibrosis
- Авторлар: Bozhkov A.I.1, Nikitchenko Y.V.1, Klimova E.M.2, Linkevych O.S.1, Lebid K.M.1, Al-Bahadli A.M.1, Alsardia M.M.1
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Мекемелер:
- Research Institute of Biology
- V.T. Zaycev State Institute of General and Urgent Surgery
- Шығарылым: Том 7, № 1 (2017)
- Беттер: 41-50
- Бөлім: Article
- URL: https://journals.rcsi.science/2079-0570/article/view/205511
- DOI: https://doi.org/10.1134/S2079057017010040
- ID: 205511
Дәйексөз келтіру
Аннотация
We investigated the role of pro- and antioxidant and immune systems in age-related adaptive reactions to chronic exposure to toxicants (copper ions). For this purpose, we administered multiple doses of copper sulfate to younger and older rats in order to induce liver fibrosis and then measured the parameters of proand antioxidant and immune systems and physiological indices. It was found that Cu-induced liver fibrosis was accompanied by oxidative stress and a significant reduction in cell-mediated immune activity. If oxidative stress was eliminated by the administration of exogenous antioxidants (mix factor), the physical capacity, body weight, and content of red blood cells in rats with fibrosis was recovered. The parameters of cell-mediated immune response recovered more effectively in older animals than in younger ones. The metabolic strategies of adaptation to toxic exposure were different in younger and older animals.
Негізгі сөздер
Авторлар туралы
A. Bozhkov
Research Institute of Biology
Хат алмасуға жауапты Автор.
Email: bozhkov@univer.kharkov.ua
Украина, Kharkiv, 61022
Yu. Nikitchenko
Research Institute of Biology
Email: bozhkov@univer.kharkov.ua
Украина, Kharkiv, 61022
E. Klimova
V.T. Zaycev State Institute of General and Urgent Surgery
Email: bozhkov@univer.kharkov.ua
Украина, Kharkiv, 61103
O. Linkevych
Research Institute of Biology
Email: bozhkov@univer.kharkov.ua
Украина, Kharkiv, 61022
K. Lebid
Research Institute of Biology
Email: bozhkov@univer.kharkov.ua
Украина, Kharkiv, 61022
A. Al-Bahadli
Research Institute of Biology
Email: bozhkov@univer.kharkov.ua
Украина, Kharkiv, 61022
M. Alsardia
Research Institute of Biology
Email: bozhkov@univer.kharkov.ua
Украина, Kharkiv, 61022
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