Molecular Aspects of the Geroprotective Effect of Peptide KE in Human Skin Fibroblasts
- Авторлар: Fridman N.1, Linkova N.1,2, Polyakova V.3,4, Drobintseva A.3,5, Trofimova S.1, Kvetnoy I.3,4, Khavinson V.1,6
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Мекемелер:
- St. Petersburg Institute of Bioregulation and Gerontology
- Peter the Great St. Petersburg Polytechnic University
- Ott Research Institute of Obstetrics, Gynecology and Reproductology
- St. Petersburg State University
- St. Petersburg State Pediatric Medical University
- Pavlov Institute of Physiology, Russian Academy of Sciences
- Шығарылым: Том 8, № 3 (2018)
- Беттер: 235-238
- Бөлім: Article
- URL: https://journals.rcsi.science/2079-0570/article/view/205957
- DOI: https://doi.org/10.1134/S2079057018030050
- ID: 205957
Дәйексөз келтіру
Аннотация
Skin aging is an current problem of modern geriatric cosmetology. One promising method to decelerate the process of age-related skin changes is the use of cosmetics with short peptides. The goal of the work was to study the effect of peptide KE (Lys-Glu, Vilon) on the expression of aging markers of human fibroblasts in an in vitro model. The expression of collagen type 1 and sirtuin 6 was studied with immunofluorescent confocal microscopy in “young” and “old” cultures of skin fibroblasts. It has been found that the area of expression of collagen type 1 and sirtuin 6 decreases by 3.5 and 3.6 times, respectively, in skin fibroblast cultures with aging. Peptide KE increases the expression area of collagen type 1 in old skin fibroblast cultures by 83%; the expression area of sirtuin 6 in young and old cultures of skin fibroblasts increased by 1.6 and 2.6 times, respectively. Thus, peptide KE increases the functional activity of skin fibroblasts and decelerates their senescence.
Негізгі сөздер
Авторлар туралы
N. Fridman
St. Petersburg Institute of Bioregulation and Gerontology
Email: linkova@gerontology.ru
Ресей, St. Petersburg, 197110
N. Linkova
St. Petersburg Institute of Bioregulation and Gerontology; Peter the Great St. Petersburg Polytechnic University
Хат алмасуға жауапты Автор.
Email: linkova@gerontology.ru
Ресей, St. Petersburg, 197110; St. Petersburg, 195251
V. Polyakova
Ott Research Institute of Obstetrics, Gynecology and Reproductology; St. Petersburg State University
Email: linkova@gerontology.ru
Ресей, St. Petersburg, 199034; St. Petersburg, 199034
A. Drobintseva
Ott Research Institute of Obstetrics, Gynecology and Reproductology; St. Petersburg State Pediatric Medical University
Email: linkova@gerontology.ru
Ресей, St. Petersburg, 199034; St. Petersburg, 194353
S. Trofimova
St. Petersburg Institute of Bioregulation and Gerontology
Email: linkova@gerontology.ru
Ресей, St. Petersburg, 197110
I. Kvetnoy
Ott Research Institute of Obstetrics, Gynecology and Reproductology; St. Petersburg State University
Email: linkova@gerontology.ru
Ресей, St. Petersburg, 199034; St. Petersburg, 199034
V. Khavinson
St. Petersburg Institute of Bioregulation and Gerontology; Pavlov Institute of Physiology, Russian Academy of Sciences
Email: linkova@gerontology.ru
Ресей, St. Petersburg, 197110; St. Petersburg, 199034