Molecular Aspects of the Geroprotective Effect of Peptide KE in Human Skin Fibroblasts
- Authors: Fridman N.V.1, Linkova N.S.1,2, Polyakova V.O.3,4, Drobintseva A.O.3,5, Trofimova S.V.1, Kvetnoy I.M.3,4, Khavinson V.K.1,6
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Affiliations:
- St. Petersburg Institute of Bioregulation and Gerontology
- Peter the Great St. Petersburg Polytechnic University
- Ott Research Institute of Obstetrics, Gynecology and Reproductology
- St. Petersburg State University
- St. Petersburg State Pediatric Medical University
- Pavlov Institute of Physiology, Russian Academy of Sciences
- Issue: Vol 8, No 3 (2018)
- Pages: 235-238
- Section: Article
- URL: https://journals.rcsi.science/2079-0570/article/view/205957
- DOI: https://doi.org/10.1134/S2079057018030050
- ID: 205957
Cite item
Abstract
Skin aging is an current problem of modern geriatric cosmetology. One promising method to decelerate the process of age-related skin changes is the use of cosmetics with short peptides. The goal of the work was to study the effect of peptide KE (Lys-Glu, Vilon) on the expression of aging markers of human fibroblasts in an in vitro model. The expression of collagen type 1 and sirtuin 6 was studied with immunofluorescent confocal microscopy in “young” and “old” cultures of skin fibroblasts. It has been found that the area of expression of collagen type 1 and sirtuin 6 decreases by 3.5 and 3.6 times, respectively, in skin fibroblast cultures with aging. Peptide KE increases the expression area of collagen type 1 in old skin fibroblast cultures by 83%; the expression area of sirtuin 6 in young and old cultures of skin fibroblasts increased by 1.6 and 2.6 times, respectively. Thus, peptide KE increases the functional activity of skin fibroblasts and decelerates their senescence.
Keywords
About the authors
N. V. Fridman
St. Petersburg Institute of Bioregulation and Gerontology
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg, 197110
N. S. Linkova
St. Petersburg Institute of Bioregulation and Gerontology; Peter the Great St. Petersburg Polytechnic University
Author for correspondence.
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg, 197110; St. Petersburg, 195251
V. O. Polyakova
Ott Research Institute of Obstetrics, Gynecology and Reproductology; St. Petersburg State University
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg, 199034; St. Petersburg, 199034
A. O. Drobintseva
Ott Research Institute of Obstetrics, Gynecology and Reproductology; St. Petersburg State Pediatric Medical University
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg, 199034; St. Petersburg, 194353
S. V. Trofimova
St. Petersburg Institute of Bioregulation and Gerontology
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg, 197110
I. M. Kvetnoy
Ott Research Institute of Obstetrics, Gynecology and Reproductology; St. Petersburg State University
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg, 199034; St. Petersburg, 199034
V. Kh. Khavinson
St. Petersburg Institute of Bioregulation and Gerontology; Pavlov Institute of Physiology, Russian Academy of Sciences
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg, 197110; St. Petersburg, 199034