Luzindole accelerates the aging of estrous function of female rats

Resumo

In this paper, we investigated the dynamics of aging of the estrous function of female rats kept in the conditions of standard vivarium lighting that received luzindolee—a blocker of melatonin receptors. Every three months, daily, for two weeks, vaginal smears were taken from the animals and a cytological examination of the vaginal contents was conducted. Despite the difference in the mechanisms of the development of melatonin system failure (a decreased production of melatonin and a blockade of melatonin receptors), the effects of the influence on the ovulatory function are similar. With a blockade of melatonin receptors, an appearance of premature signs of aging of the reproductive function in rats was observed. It was manifested by an increased duration of the ovulatory cycle; a decrease in the number of regular cycles; the emergence of irregular cycles; a decrease in the number of short estrous cycles and an increase of long cycles; and the early development of persistent estrus.