Neurohumoral changes in rats of different age groups on the background of injection of cryopreserved cord blood nucleated cells
- Authors: Martynova Y.V.1, Babiychuk V.G.1, Sirotenko L.A.2, Malova N.G.2, Babiychuk L.V.1
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Affiliations:
- Institute for Problems of Cryobiology and Cryomedicine
- Danilevsky Institute for Endocrine Pathology
- Issue: Vol 6, No 4 (2016)
- Pages: 304-310
- Section: Article
- URL: https://journals.rcsi.science/2079-0570/article/view/205087
- DOI: https://doi.org/10.1134/S2079057016040093
- ID: 205087
Cite item
Abstract
The application of a cryopreserved preparation of UCB NCs to rats was accompanied by enhanced activity of all neurohumoral regulation elements of heart rate, although the absolute parameters in 18- and 24-month-old animals did not reach values similar to those in groups of younger age. We also noticed an increase of the thyroid hormone concentration in the blood serum of the old rats. The concentration decreased with age. In addition, it was shown that the injection of UCB NCs during the animal’s life cycle (every 6 months) made it possible to maintain a functional state of the autonomous nervous system at a “young” physiological level.
About the authors
Yu. V. Martynova
Institute for Problems of Cryobiology and Cryomedicine
Author for correspondence.
Email: martynova1rudnyeva@gmail.com
Ukraine, Kharkiv, 61016
V. G. Babiychuk
Institute for Problems of Cryobiology and Cryomedicine
Email: martynova1rudnyeva@gmail.com
Ukraine, Kharkiv, 61016
L. A. Sirotenko
Danilevsky Institute for Endocrine Pathology
Email: martynova1rudnyeva@gmail.com
Ukraine, Kharkiv, 61002
N. G. Malova
Danilevsky Institute for Endocrine Pathology
Email: martynova1rudnyeva@gmail.com
Ukraine, Kharkiv, 61002
L. V. Babiychuk
Institute for Problems of Cryobiology and Cryomedicine
Email: martynova1rudnyeva@gmail.com
Ukraine, Kharkiv, 61016