Molecular Mechanisms of Aging: The Role of Oxidative Stress and Epigenetic Modifications


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Abstract

Aging is a multifactorial process characterized by a gradual loss of physiological functions, which leads to increased vulnerability of the organism to age-related diseases and, finally, to death. Several theories have been proposed to explain the nature of aging, one of which relates aging to the damage to cell structures and DNA caused by free radicals. However, an increasing amount of evidence suggests that the molecular mechanisms of aging are also associated with epigenetic modifications, such as DNA methylation, noncoding RNA and histone changes. In this review, we will analyze the significance of the results of these studies and show how the interrelated effects of oxidative stress and epigenetics can explain the cause of the extinction of physiological functions during aging.

About the authors

K. A. Aitbaev

Scientific and Research Institute of Molecular Biology and Medicine

Email: murkamilov.i@mail.ru
Kyrgyzstan, Bishkek, 720040

I. T. Murkamilov

Akhunbaev Kyrgyz State Medical Academy; First President of Russia B.N. Yeltsin Kyrgyz Russian Slavic University

Author for correspondence.
Email: murkamilov.i@mail.ru
Kyrgyzstan, Bishkek, 720020; Bishkek, 720000

V. V. Fomin

Sechenov First Moscow State Medical University

Email: murkamilov.i@mail.ru
Russian Federation, Moscow, 119991

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