Comparative Analysis of Experimental Data on the Effects of Different Polyphenols on Lifespan and Aging

Abstract

Survival curves were approximated and analyzed based on experimental data on the effect of different polyphenolic compounds on mouse lifespan with the Gompertz model in its minimal variant, which excludes the parameters of sample heterogeneity and age-independent mortality. Vectors from the control data towards the experimental data were plotted on graphs with coordinates [logμ₀ (the logarithm of initial mortality) and γ (the rate of aging)] and compared with a series of control points. The deviations were considered real when the tilt angles of the corresponding vectors differed from those of the logμ₀ regressions on the γ coordinate based on the control data. The results of analysis of the published data have shown that resveratrol, tocopherol, polyphenol-containing grape skin extract, SkQ1 antioxidant, and metformin do not result in any differences between the control and experimental data beyond the limits expected in the comparison of different samples of the same control population. Unlike the indicated preparations, the complex polyphenol preparation BP-C3 acts differently and decelerates aging in female SHR mice. It is the antioxidant activity of BP-C3 that may partly be associated with this effect. We have determined its antioxidant capacity in vitro, and demonstrated its ability when administered in vivo to hinder a decrease in the total peroxide-decomposing activity in the erythrocytes of male BALB/c mice treated with 5-fluorouracil.