Impact of the Transplantation of Multipotent Mesenchymal Stromal Cells after Liver Resection on Blood Biochemical Parameters in Mature and Old Laboratory Animals


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Abstract

The goal of this study is to examine the effect of the transplantation of multipotent mesenchymal stromal cells (MMSCs) on blood biochemical parameters after liver resection in mature and old laboratory animals. The studies show the ability of old laboratory animals to respond to MMSC transplantation after liver resection by reducing the severity of hepatocyte cytolysis. Comparative analysis of the biochemical parameters of mature and old laboratory animals after liver resection has revealed a more pronounced response in the liver ability to synthesize urea in mature animals.

About the authors

I. Yu. Maklakova

Ural State Medical University; Institute of Medical Cell Technologies

Email: dr-grebnev77@mail.ru
Russian Federation, Yekaterinburg, 620000; Yekaterinburg, 620026

D. Yu. Grebnev

Ural State Medical University; Institute of Medical Cell Technologies

Author for correspondence.
Email: dr-grebnev77@mail.ru
Russian Federation, Yekaterinburg, 620000; Yekaterinburg, 620026

V. Ch. Yusupova

Institute of Medical Cell Technologies

Email: dr-grebnev77@mail.ru
Russian Federation, Yekaterinburg, 620026

I. V. Gavrilov

Ural State Medical University; Institute of Medical Cell Technologies

Email: dr-grebnev77@mail.ru
Russian Federation, Yekaterinburg, 620000; Yekaterinburg, 620026

E. A. Primakova

Republican Scientific and Practical Center for Organ and Tissue Transplantation,
9th City Clinical Hospital

Email: dr-grebnev77@mail.ru
Belarus, Minsk, 220027

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