The Effect of Cryopreserved Cord Blood Nucleated Cells on Pathological Processes in the Progressive Aging of the Brain (Experimental Study)

Abstract

This work presents data on morphometric indices of the vascular bed and brain substance of spontaneously hypertensive SHR rats, which may be considered evidence of the developing pathological brain aging processes in these animals. Chronic alcohol intoxication aggravates the neurodegeneration, significantly reducing the indices of the neuroglial index, the number of functioning vessels and activating the LPO processes. A single intraperitoneal administration of cryopreserved human cord blood nucleated cells in a dose of (1–5) × 10⁷/kg promoted the regeneration of neurocells, the stimulation of angiogenesis and an increased level and quality of neurotissue metabolism, reducing the signs of dystrophic, destructive and pathologically altered compensatory adaptive processes in the rat’s brain as a result of the restoration of its microhemocirculation and cytoarchitecture.