Age-Related Peculiarities of Cytogenetic Disorders in Synovial Cells of Knee Joints in Northern Siberian Residents with Arthritis of Various Etiologies due to Polymorphism of the Glutathione S-Transferase Gene GSTM1

Abstract

The frequency of cells with cytogenetic disorders in the synovial fluid cells of the knee joints was studied in patients of different age groups with chronic arthritis associated with Lyme borreliosis (CAALB) or posttraumatic arthritis (PTA) with respect to polymorphism in the glutathione S-transferase gene GSTM1. One hundred thirty five residents of the north of Tomsk and Tyumen oblasts were included in the study; 68 of them suffered from CAALB, while PTA was detected in the remaining 67 patients comprising the control group. Our results indicate the presence of significant age-related differences in the frequency of cytogenetic disorders in the synovial fluid cells of the knee joints between the groups of young and elderly CAALB patients. An integrative estimation of clinical and cytogenetic indices in the group of elderly CAALB patients (carriers of the mutant GSTM1 (0/0) allele) as compared with other groups allows the conclusion that there are significant positive correlations between the severity of violation of the locomotor function of the joints and the number of the synovial fluid cells with chromosome 7 trisomy.