Pineamin Increases Melatonin Synthesis in Pineal Gland of Elderly People
- Authors: Trofimova S.V.1, Linkova N.S.1,2, Klimenko A.A.3, Kvetnaia T.V.1, Khavinson V.K.1,4
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Affiliations:
- St. Petersburg Institute of Bioregulation and Gerontology
- Peter the Great St. Petersburg Technical University
- Geropharm Group of Companies
- Pavlov Institute of Physiology
- Issue: Vol 7, No 4 (2017)
- Pages: 319-322
- Section: Article
- URL: https://journals.rcsi.science/2079-0570/article/view/205866
- DOI: https://doi.org/10.1134/S2079057017040130
- ID: 205866
Cite item
Abstract
The effect of a pineal gland polypeptide complex, Pineamin, on urine excretion of 6-sulfatoxymelatonin (6-SOMT) was investigated by immunoenzyme assay in 55 elderly patients with decreased melatonin formation. Pineamin at a dose of 100 mg increased the level of 6-SOMT excretion in overnight urine by 1.9 times in comparison with the respective indicator before the treatment. A similar effect was previously obtained upon the administration of Epitalamin, which also facilitated the restoration of melatonin synthesis in human and animal pineal glands affected by aging. Hence, Pineamin and Epitalamin exhibit a one-directional stimulating property with respect to the melatonin-forming function of the pineal gland in elderly people.
Keywords
About the authors
S. V. Trofimova
St. Petersburg Institute of Bioregulation and Gerontology
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg, 197110
N. S. Linkova
St. Petersburg Institute of Bioregulation and Gerontology; Peter the Great St. Petersburg Technical University
Author for correspondence.
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg, 197110; St. Petersburg, 195251
A. A. Klimenko
Geropharm Group of Companies
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg, 191144
T. V. Kvetnaia
St. Petersburg Institute of Bioregulation and Gerontology
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg, 197110
V. Kh. Khavinson
St. Petersburg Institute of Bioregulation and Gerontology; Pavlov Institute of Physiology
Email: linkova@gerontology.ru
Russian Federation, St. Petersburg, 197110; St. Petersburg, 199034