Interrelation of Biological Aging Rates with Neurophysiological Features in Patients with Occupational Neurointoxications

Abstract

Brain functional activity was studied patients hospitalized with occupational neurontoxications in order to reveal the neurophysiological features of the development of accelerated biological aging in working persons exposed to neurotoxicants. The study showed that patients with occupational neurointoxications are characterized in an average of 85% cases by premature aging. The typical neurophysiological feature of this contingent is an increased latency of the P2 peak of visual evoked potentials. The common signs of lesions of cerebral structures in occupational mercury intoxication in accelerated biological aging were determined, irrespective of the disease stage. On the basis of the analysis of the correlations, it is established that the consequence of chronic exposure to metal mercury vapors and the cause of accelerated biological aging at occupational neurointoxications is a permanent disorganization of the functional activity of the brain, which manifests itself as cortical and subcortical disturbances of sensory regulatory systems of the brain.