Content of proinflammatory cytokines, peroxiredoxin-1, and activity of glutathione peroxidase in blood plasma of coronary artery disease patients after coronary artery bypass grafting

Abstract

An examination of a group of 76 CAD patients after coronary artery bypass grafting was performed with the goal to investigate the role of proinflammatory cytokines and enzymes participating in redox regulation in the mechanisms of development of systemic inflammation response and pathogenesis of postpericardiotomy syndrome (PPS). The patients were divided into two groups: the first group was CAD patients that were not diagnosed with PPS based on clinical examination, and the second group was CAD patients diagnosed with PPS. The enhancements of IL-6 and IL-8 production, as well as imbalance in the functions of peroxiredoxin-1 and glutathione peroxidase, was observed in the blood plasma of the patients from both groups. These changes were observed at earlier stages in the patients with PPS, and they were more substantial. The results of this work confirmed the high efficiency of the investigated indicators for prevention and monitoring of the PPS development.