The role of Alu polymorphism of PLAT, PKHD1L1, STK38L, and TEAD1 genes in development of a longevity trait

Abstract

The Alu(I/D) polymorphism of the PLAT (TPA25), PKHD1L1 (Yb8AC702), STK38L (Ya5ac2145), and TEAD1 (Ya5ac2013) genes was for the first time characterized in an ethnically homogeneous group of Tatars living in the Republic of Bashkortostan, and the association of Alu(I/D) polymorphism in each of the genes with age was established. The study group included 1580 individuals unrelated to each other (21–109 years), including 204 with long lives. The STK38L*I/D genotype is positively associated with longevity in a total group of men and women (OR = 1.016, p = 0.034). The probability of detection of the PKHD1L1*I/I (OR = 1.289, p = 0.009), PLAT*D/D (OR = 1.175, p = 0.016), and TEAD1*I/I (OR = 1.047, p = 0.042) genotypes is increased in women who reached the age of longevity. The PKHD1L1*I/D genotype was significant for reaching the age of longevity in men (OR = 1.713, p = 0.03). Thus, a character of change in the genotype frequency according to Alu(I/D) polymorphic sites depending on age is specific for each individual gene.