Musculoskeletal system as a target organ of frailty processes

Abstract

Pathology of the musculoskeletal system is widespread in the population and is one of the most common diseases in patients of older age groups. The most significant are osteoporosis, osteoarthritis, and sarcopenia. All three components separately, of course, lead to lower quality of life. We show the mechanisms of their interaction and their combined impact on the musculoskeletal system as a target organ of senile asthenia processes. Osteoarthritis, osteoporosis, sarcopenia, and especially their combination lead to hypomobility. Hypomobility under the action of external factors is one of the leading syndromes that can potentially aggravate senile asthenia processes. This triggers the reentry mechanism, and a vicious circle forms, leading to fatal medical-social and social consequences. It is shown that changes in the musculoskeletal system should be considered as a single aging problem of senile asthenia, and all previous and newly created medicalsocial rehabilitation and prevention programs should have an integrated nature.