Age-related changes in biogenic amine content and oxidative stress profile in rat hypothalamus with hyperhomocysteinemia

Abstract

The article presents a detailed analysis of correlations between the content of a variety of biogenic amines in the hypothalamic structures responsible for the gonadotropin-releasing hormone synthesis and secretion (the medial preoptic area and median eminence), and such independent factors as total L-homocysteine plasma level elevation induced by L-methionine loading and aging. Both the nature and pattern of changes in oxidative stress profile were evaluated. It was shown that aging, when compared to hyperhomocysteinemia, is a determining factor influencing the biogenic amine content in the studied hypothalamic structures. Unlike the antioxidant defense system profile, no considerable changes in macromolecule oxidative modification were found, which is evidence of a balanced activity of pro- and antioxidant systems in the hypothalamus.