Demyelinating CNS processes in late post-liver transplant period

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In solid organ recipients, post-transplant neurotoxicity of calcineurin inhibitors (CIs) can be manifested by brain and spinal cord demyelination with multiple sclerosis (MS)-like symptoms.

Here are presented two case reports of neurological MS-like symptoms in the long-term post-liver transplant period with different underlying causes.

CI neurotoxicity may resemble various neurological diseases, including MS. At the same time, liver transplant recipients can develop true MS regardless of the immunosuppressant use. In liver transplant recipients, adequate differential diagnosis of neurological complications avoids unnecessary medications and reverses severe neurological deficits by immunosuppressant conversion.

作者简介

Anastasia Salienko

Sklifosovsky Research Institute for Emergency Medicine

编辑信件的主要联系方式.
Email: salienko1@mail.ru
ORCID iD: 0000-0002-2732-684X

surgeon, Emergency operations unit, Moscow City Center for Liver Transplantation, Sklifosovsky Research Institute for Emergency Medicine, Moscow, Russia

俄罗斯联邦, Moscow

Vladimir Syutkin

Sklifosovsky Research Institute for Emergency Medicine

Email: vladsyutkin@gmail.com
ORCID iD: 0000-0001-8391-5211

D. Sci. (Med.), leading researcher, Moscow City Center for Liver Transplantation, Sklifosovsky Research Institute for Emergency Medicine, Moscow, Russia

俄罗斯联邦, Moscow

Maria Lisitskaya

Lomonosov Moscow State University

Email: lissenok@inbox.ru
ORCID iD: 0000-0002-8402-7643

Cand. Sci. (Med.), radiologist, Department of X-ray diagnostics with CT and MRI rooms, Lomonosov Moscow State University, Moscow, Russia

俄罗斯联邦, Moscow

Denis Kuznetsov

Moscow Scientific and Practical Center of Dermatology, Venerology and Cosmetology

Email: doktor.nevrolog@mail.ru
ORCID iD: 0000-0002-8201-2376

neurologist, Moscow Scientific and Practical Center of Dermatology, Venerology and Cosmetology, Moscow, Russia

俄罗斯联邦, Moscow

Murad Novruzbekov

Sklifosovsky Research Institute for Emergency Medicine

Email: n.m.s@bk.ru
ORCID iD: 0000-0002-6362-7914

D. Sci. (Med.), Head, Scientific Department, Moscow City Center for Liver Transplantation, Sklifosovsky Research Institute for Emergency Medicine, Moscow, Russia

俄罗斯联邦, Moscow

参考

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2. Fig. 1. Brain changes in patient Z (female).

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3. Fig. 2. Brain changes in patient K. (male).

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版权所有 © Салиенко А., Сюткин В., Лисицкая М., Кузнецов Д., Новрузбеков М., 2023

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