Demyelinating CNS processes in late post-liver transplant period

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Abstract

In solid organ recipients, post-transplant neurotoxicity of calcineurin inhibitors (CIs) can be manifested by brain and spinal cord demyelination with multiple sclerosis (MS)-like symptoms.

Here are presented two case reports of neurological MS-like symptoms in the long-term post-liver transplant period with different underlying causes.

CI neurotoxicity may resemble various neurological diseases, including MS. At the same time, liver transplant recipients can develop true MS regardless of the immunosuppressant use. In liver transplant recipients, adequate differential diagnosis of neurological complications avoids unnecessary medications and reverses severe neurological deficits by immunosuppressant conversion.

About the authors

Anastasia A. Salienko

Sklifosovsky Research Institute for Emergency Medicine

Author for correspondence.
Email: salienko1@mail.ru
ORCID iD: 0000-0002-2732-684X

surgeon, Emergency operations unit, Moscow City Center for Liver Transplantation, Sklifosovsky Research Institute for Emergency Medicine, Moscow, Russia

Russian Federation, Moscow

Vladimir E. Syutkin

Sklifosovsky Research Institute for Emergency Medicine

Email: vladsyutkin@gmail.com
ORCID iD: 0000-0001-8391-5211

D. Sci. (Med.), leading researcher, Moscow City Center for Liver Transplantation, Sklifosovsky Research Institute for Emergency Medicine, Moscow, Russia

Russian Federation, Moscow

Maria V. Lisitskaya

Lomonosov Moscow State University

Email: lissenok@inbox.ru
ORCID iD: 0000-0002-8402-7643

Cand. Sci. (Med.), radiologist, Department of X-ray diagnostics with CT and MRI rooms, Lomonosov Moscow State University, Moscow, Russia

Russian Federation, Moscow

Denis V. Kuznetsov

Moscow Scientific and Practical Center of Dermatology, Venerology and Cosmetology

Email: doktor.nevrolog@mail.ru
ORCID iD: 0000-0002-8201-2376

neurologist, Moscow Scientific and Practical Center of Dermatology, Venerology and Cosmetology, Moscow, Russia

Russian Federation, Moscow

Murad S. Novruzbekov

Sklifosovsky Research Institute for Emergency Medicine

Email: n.m.s@bk.ru
ORCID iD: 0000-0002-6362-7914

D. Sci. (Med.), Head, Scientific Department, Moscow City Center for Liver Transplantation, Sklifosovsky Research Institute for Emergency Medicine, Moscow, Russia

Russian Federation, Moscow

References

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2. Fig. 1. Brain changes in patient Z (female).

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3. Fig. 2. Brain changes in patient K. (male).

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Copyright (c) 2023 Salienko A.A., Syutkin V.E., Lisitskaya M.V., Kuznetsov D.V., Novruzbekov M.S.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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