MicroRNA detection in carotid atherosclerosis: prospects for clinical use

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Abstract

Carotid atherosclerosis is a significant cause of cerebrovascular disease. However, with many candidate markers, precise assessment of its development and progression risks is still limited. This paper reviews state-of-the-art concepts of microRNA as an atherogenesis biomarker throughout various stages including endothelial dysfunction, cholesterol/lipid metabolism, inflammation, oxidative stress, angiogenesis regulation, and proliferation and migration of vascular smooth muscle cells. Based on the available literature, we have described most significant microRNAs for each stage characterized in brief. We have visualized interactions between microRNAs and validated target genes with MIENTURNET and suggest and justify a set of microRNAs for further pilot studies of carotid atherosclerosis.

About the authors

Мarine М. Tanashyan

Research Center of Neurology

Email: mtanashyan@neurology.ru
ORCID iD: 0000-0002-5883-8119

D. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences, Deputy Director for Research, Head, 1st Neurological Department, Research Center of Neurology

Russian Federation, Moscow

Anton A. Rakurazhev

Research Center of Neurology

Author for correspondence.
Email: rasckey@live.com
ORCID iD: 0000-0003-0522-767X

Cand. Sci. (Med.), Neurologist, Senior Researcher, 1st Neurological Department, Research Center of Neurology

Russian Federation, Moscow

Polina I. Kuznetsova

Research Center of Neurology

Email: angioneurology0@gmail.com
ORCID iD: 0000-0002-4626-6520

Cand. Sci. (Med.), Neurologist, Researcher, 1st Neurological Department, Research Center of Neurology

Russian Federation, Moscow

Andrew S. Mazur

Research Center of Neurology

Email: a1699466@yandex.ru
ORCID iD: 0000-0001-8960-721X

Postgraduate Student, 1st Neurological Department, Research Center of Neurology

Russian Federation, Moscow

Аlla A. Shabalina

Research Center of Neurology

Email: ashabalina@yandex.ru
ORCID iD: 0000-0001-9604-7775

D. Sci. (Med.), Leading Researcher, Head, Laboratory of Hemorheology, Hemostasis and Pharmacokinetics (with Clinical Laboratory Diagnostics), Research Center of Neurology

Russian Federation, Moscow

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Supplementary files

Supplementary Files
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2. Fig. 1. MicroRNAs associated with endothelial dysfunction (rectangles on white) and their targets (ellipses on green).

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3. Fig. 2. MicroRNAs associated with lipid metabolism (rectangles on white) and their targets (ellipses on green).

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4. Fig. 3. MicroRNAs associated with inflammation (rectangles on white) and their targets (ellipses on green).

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5. Fig. 4. MicroRNAs associated with angiogenesis regulation and proliferation of smooth muscle cells (rectangles on white) and their targets (ellipses on green).

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Copyright (c) 2023 Tanashyan М.М., Rakurazhev A.A., Kuznetsova P.I., Mazur A.S., Shabalina А.A.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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