Creutzfeldt-Jakob disease (CJD) is a form of human prion diseases, fatal neurodegenerative conditions. They can be etiologically divided into sporadic, hereditary and acquired forms. Conformational change of the normal (cellular) form of prion protein (PrPc) to a pathological form (PrPSс) is a central event in the formation of an infectious agent. In this article, diagnostic criteria for sporadic CJD are summarized. Case report of probable sporadic CJD is presented. Many therapeutic strategies (based on cell cultures or animals) have been tested as potential treatments for prion diseases. However, only few clinical trials are in progress now or have been completed.
Sporadic Creutzfeldt-Jakob disease: clinical observation
- Authors: Peresedova A.V.1, Stoida N.I.1, Gnezdizky V.V.1, Konоvаlоv R.N.1, Kоrеpina O.S.1, Zavalishin I.A.1
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Affiliations:
- Research Center of Neurology, Russian Academy of Medical Sciences (Моscow)
- Issue: Vol 5, No 4 (2011)
- Pages: 52-56
- Section: Original articles
- URL: https://journals.rcsi.science/2075-5473/article/view/124513
- DOI: https://doi.org/10.17816/psaic288
- ID: 124513
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About the authors
A. V. Peresedova
Research Center of Neurology, Russian Academy of Medical Sciences (Моscow)
Author for correspondence.
Email: platonova@neurology.ru
Russian Federation
N. I. Stoida
Research Center of Neurology, Russian Academy of Medical Sciences (Моscow)
Email: platonova@neurology.ru
Russian Federation
V. V. Gnezdizky
Research Center of Neurology, Russian Academy of Medical Sciences (Моscow)
Email: platonova@neurology.ru
Russian Federation
R. N. Konоvаlоv
Research Center of Neurology, Russian Academy of Medical Sciences (Моscow)
Email: platonova@neurology.ru
Russian Federation
O. S. Kоrеpina
Research Center of Neurology, Russian Academy of Medical Sciences (Моscow)
Email: platonova@neurology.ru
Russian Federation
I. A. Zavalishin
Research Center of Neurology, Russian Academy of Medical Sciences (Моscow)
Email: platonova@neurology.ru
Russian Federation
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