COMPARATIVE PHARMACOEPIDEMIOLOGICAL CHARACTERISTICS OF THE PRESCRIPTIONS OF MEDICINES APPLIED AT PATIENTS WITH CHRONIC HEART FAILURE IN THE CONDITIONS OF TYPICAL PRACTICE OF KURSK AND CHISINAU

Aim. To study structure of the medical prescriptions of medicines applied at patients with chronic heart failure in the conditions of typical practice of Kursk (Russian Federation) and Chisinau (Republic of Moldova). Materials and methods. During the period from October, 2017 to January, 2018 as a one-stage descriptive research, questioning of doctors of the medical organizations of Kursk and Chisinau was carried out. Questionnaires included questions on pharmacoepidemiological aspects of prescription of medicines, the patients with chronic heart failure applied to treatment. Total number of respondents was 118, of them 54 (1 cardiologist and 53 therapists) - in Kursk and 64 (8 cardiologists and 56 therapists) - in Chisinau. Results. Doctors of Kursk and Chisinau have no statistically significant differences in structure of appointments of the main groups of the drugs used at patients with chronic heart failure except for inhibitor of If-channels (ivabradine) which was used to a thicket (p<0.05) in practical work of the Kursk doctors. Priority of the choice of certain representatives of inhibitors of an angiotensin-converting enzyme authentically differed in the considered regions: the Kursk doctors are more often (p<0.001) appointed perindopril and fozinopril, the Chisinau doctors - ramipril and captopril (p<0.05, p<0.01, respectively). From among blockers of receptors of angiotensin II, a share of application of a valsartan, a kandesartan were comparable in structure of appointments of the Kursk and Chisinau doctors (p>0.05), losartan to a thicket (p<0.01) used p in Chisinau. Significant differences between the explored regions on use of the main representatives of group a betablockers (bisoprolol, carvedilol, metoprolol succinate, nebivolol) it was not revealed (p>0.05). The group of mineralocorticoid receptor antagonists was presented spironolactone, occupying 90.7% and 90.9% in structure of appointments of doctors of Chisinau and Kursk, respectively. The analysis of appointment of other representatives of diuretics showed share parity (p>0.05) in the compared regions. At the list of appointments from among sartan and beta blockers there were medicines which are not characterized by expediency of application for the considered contingent of patients. Conclusion. Comparison of structure of purposes of classes of the drugs used for therapy of patients with chronic heart failure to the existing clinical recommendations, demonstrates that doctors of Chisinau and Kursk realize pharmacotherapy of the specified contingent of patients according to modern requirements of protocols and recommendations about maintaining patients with the specified pathology. At the same time, cases of irrational prescription of certain drugs in patients with chronic heart failure are recorded.

pharmacoepidemiology, chronic heart failure