Pharmacological validity of amlodipine, lisinopril and rosuvastatin in three-component combination drug products

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Abstract

The development of combined drugs, including antihypertensive and hypolipidemic components, represents the important stage in the clinical pharmacology funds for the treatment and prevention of cardiovascular disease complications. This approach allows significantly increase the degree of adherence of patients to treatment. The interactions between the drug components should be minimal or absent to improve the efficacy and safety of combined drug application. The article shows the significant data concerning the pharmacological validity of the combined application of dihydropyridine calcium channel blockers, amlodipine, angiotensin-converting enzyme inhibitors lisinopril and rosuvastatin; the most widely used drugs - statins.

About the authors

S. R Giliarevskiy

Russian Medical Academy of Postgraduate Education of the Ministry of Health of the Russian Federation

Email: sgilarevsky@rambler.ru
д-р мед. наук, проф. каф. клин. фармакологии и терапии ГБОУ ДПО РМАПО 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

M. V Golshmid

Russian Medical Academy of Postgraduate Education of the Ministry of Health of the Russian Federation

канд. мед. наук, доц. каф. клин. фармакологии и терапии ГБОУ ДПО РМАПО 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

I. M Kuzmina

N.V.Sklifosovsky Research Institute of Emergency Medicine of the Department of Health of Moscow

канд. мед. наук, зав. науч. отд-нием неотложной кардиологии ГБУЗ НИИ СП им. Н.В.Склифосовского 129090, Russian Federation, Mosсow, Bol'shaia Sukharevskaia pl., d. 3

G. Yu Zakharova

Russian Medical Academy of Postgraduate Education of the Ministry of Health of the Russian Federation

канд. мед. наук, доц. каф. клин. фармакологии и терапии ГБОУ ДПО РМАПО 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

I. I Sinitsina

Russian Medical Academy of Postgraduate Education of the Ministry of Health of the Russian Federation

д-р мед. наук, проф. каф. клин. фармакологии и терапии ГБОУ ДПО РМАПО 125993, Russian Federation, Moscow, ul. Barrikadnaia, d. 2/1

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