Nonalcoholic fatty liver disease and type 2 diabetes mellitus

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Abstract

Diabetes mellitus type 2 (DM 2) is often associated with non - alcoholic fatty liver disease (NAFLD). The combination of type 2 diabetes and NAFLD is associated with a high risk of developing liver cirrhosis and hepatocellular carcinoma in patients with data. All aspects of the pathogenesis of NAFLD is unknown until the end, but a key role for insulin resistance. A new class of oral antidiabetic drugs - inhibitors of sodium - glucose cotransporter type 2 (inhibitors of SGLT2) - reduce the level of blood glucose independent of insulin manner. SGLT2 inhibitors lead to a decrease in body weight, thereby reducing insulin resistance, hyperinsulinemia, and glucose normalization synthesis and its utilization in the liver. This class of antidiabetic drugs may have positive effects on NAFLD and be used to treat patients with a combination of type 2 diabetes and NAFLD.

About the authors

S. V Rodionova

Moscow Clinical Science-Practical Center of the Department of Health of Moscow

врач-эндокринолог ГБУЗ МКНЦ 111123, Russian Federation, Moscow, sh. Entuziastov, d. 86

L. A Zvenigorodskaya

Moscow Clinical Science-Practical Center of the Department of Health of Moscow

Email: msll@rambler.ru
д-р мед. наук, проф. ГБУЗ МКНЦ 111123, Russian Federation, Moscow, sh. Entuziastov, d. 86

E. V Biryukova

A.I.Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health of the Russian Federation

д-р мед. наук, проф. ГБОУ ВПО МГМСУ им. А.И.Евдокимова 127473, Russian Federation, Moscow, ul. Delegatskaia, d. 20, str. 1

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