Clinical and pharmacological aspects of the use of vitamin D: from the known facts to look for new targets

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Abstract

Vitamin D not only occupies an important place in the regulation of calcium-phosphorus homeostasis, but also has many "non-bone" effects. Revealed in epidemiological studies the link between vitamin D deficiency and the development of various diseases is currently under study in randomized clinical trials. Severity of clinical effects of vitamin D may be dependent on the genetic polymorphism of VDR (vitamin receptors D), over - expressed in the 40 target tissues. For the prevention and treatment of vitamin D- deficient conditions and insolation recommended application of vitamin D, in particular, its active metabolite alfacalcidol is used.

About the authors

O. Yu Klimova

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Email: oklimova2009@gmail.com
врач-эндокринолог, ассистент каф. клин. фармакологии и пропедевтики внутренних болезней ГБОУ ВПО Первый МГМУ им. И.М.Сеченова 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

N. G Berdnikova

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation; I.M.Davidovckiy City Clinical Hospital №23

Email: berdnad@mail.ru
канд. мед. наук, доц. каф. клин. фармакологии и пропедевтики внутренних болезней ГБОУ ВПО Первый МГМУ им. И.М.Сеченова, врач - клинический фармаколог ГБУЗ ГКБ №23 им. И.В.Давыдовского 119027, Russian Federation, Moscow, ul. Iauzskaia, d. 11

R. E Kazakov

Scientific Center for Expertise of Pharmaceuticals for Medical Use of the Ministry of Health of the Russian Federation

Email: rustic100@rambler.ru
канд. биол. наук, нач. отд. персонализированной медицины и клин. фармакогенетики Центра клинической фармакологии ФГБУ НЦЭСМП 127051, Russian Federation, Moscow, Petrovskii b-r, d. 8

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