Ultra-long-acting b2-agonists in the treatment of chronic obstructive pulmonary disease and bronchial asthma

Cover Page

Cite item

Full Text

Abstract

B2-Agonists are effective bronchodilators due primarily to their ability to relax airway smooth muscle. Short-acting b2- agonists provide rapid as-needed symptom relief and short-term prophylactic protection against bronchoconstriction induced by exercise or other stimuli. But it was very important to increase compliance of control regimen of bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) medication. The 12-hours duration showed compliance increasing due to twice administration per day. Creating ultra-long-acting b2-agonists having a rapid onset of effect and acceptable safety profile with once-daily dose administration, is an important strategy to improve adherence and is a regimen preferred by most patients, which may also lead to enhancement of compliance, and may have advantages leading to improved overall clinical outcomes due to long-term and stability bronchodilating effect.

About the authors

M. A Koutsenko

N.I.Pirogov Russian National Research Medical University of the Ministry of Health of the Russian Federation; Research Institute for Pulmonology

Email: mkmed@yandex.ru
канд. мед. наук, доц. каф. госпитальной терапии ГБОУ ВПО РНИМУ им. Н.И.Пирогова, ст. науч. сотр. лаб. клин. фармакологии ФГБУ НИИ пульмонологии 117997, Russian Federation, Moscow, ul. Ostrovitianova, d. 1

References

  1. Государственный реестр лекарственных средств. http://grls.rosminzdrav.ru
  2. Barnes P.J, Liu S.F. Regulation of pulmonary vascular tone. Pharmacol Rev 1995; 47 (1): 87-131.
  3. Battram C, Charlton S.J, Cuenoud B et al. In vitro and in vivo pharmacological characterization of 5-[(R)-2-(5.6-diethyl - indan-2-ylamino)-1-hydroxy - ethyl]-8-hydroxy-1H-quinolin-2-one (indacaterol), a novel inhaled b2-adrenoceptor agonist with a 24-h duration of action. J Pharmacol Exp Ther 2006; 317: 762-70.
  4. Bourke D, Warlry A. The steady state and rebreathing methods compared during morphine administration in humans. J Physiol 1989; 419: 509-17.
  5. Brookman L.J, Knowles L.J, Barbier M et al. Efficacy and safety of single therapeutic and supratherapeutic doses of indacaterol versus salmeterol and salbutamol in patients with asthma. Curr Med Res Opin 2007; 23: 3113-22.
  6. Campbell L.M. Once - daily inhaled corticosteroids in mild to moderate asthma: improving acceptance of treatment. Drugs 1999; 58 (Suppl. 4): 25-33.
  7. Carstairs J.R, Nimmo A.J, Barnes P.J. Autoradiographic visualization of beta - adrenoceptor subtypes in human lung. Am Rev Respir Dis 1985; 132 (3): 541-7.
  8. Cazzola M, Page C.P, Calzetta L, Matera M.G. Pharmacology and Therapeutics of Bronchodilators. Pharmacol Rev 2012; 64: 450-504.
  9. Celli B, Benditt J, Albert R. Chronic Obstructive Pulmonary Disease. Comprehensive Respiratory Medicine, edited by R.Albert, S.Sriro, J.J.Mosby. 1999; 37: 1-37.
  10. Chowdhury B.A, Dal Pan G. The FDA and safe use of long - acting beta - agonists in the treatment of asthma. N Engl J Med 2010; 362 (13): 1169-71.
  11. Chuchalin A.G, Tsoi A.N, Richter K et al. Safety and tolerability of indacaterol in asthma: a randomized, placebo - controlled 28-day study. Respir Med 2007; 101: 2065-75.
  12. Cope S, Capkun-Niggli G, Gale R et al. Comparative efficacy of indacaterol 150/xg and 300/xg versus fixeddose combinations of formoterol + budesonide or salmeterol + fluticasone for the treatment of chronic obstructive pulmonary disease - a network metaanalysis. Int J Chron Obstruct Pulm Dis 2011; 6: 329-44.
  13. Dahl R, Chung K.F, Buhl R et al. Efficacy of a new once - daily LABA, indacaterol, versus the twice - daily LABA, formoterol, in COPD. Thorax 2010; 65: 473-9.
  14. Donohue J.F, Fogarty C, Lotvall J et al. Once - daily bronchodilators for chronic obstructive pulmonary disease: indacaterol versus tiotropium. Am J Respir Crit Care Med 2010; 182: 155-62.
  15. Edsbäcker S. Pharmacological factors that influence the choice of inhaled corticosteroids. Drugs 1999; 58 (Suppl. 4):7-16.
  16. Feldman G, Siler T, Prasad N et al. INLIGHT 1study group. Efficacy and safety of indacaterol 150 microg once - daily in COPD: a double blind, randomised, 12-week study. BMC Pulm Med 2010; 10: 11.
  17. Ferguson G.T, Feldman G.J, Hofbauer P et al. Efficacy and safety of olodaterol once daily delivered via RespimatR in patients with GOLD 2-4 COPD: results from two replicate 48-week studies. Int J Chron Obstruct Pulm Dis 2014; 9: 629-45.
  18. Fletcher M.J, Upton J, Taylor-Fishwick J et al. COPD uncovered: an international survey on the impact of chronic obstructive pulmonary disease [COPD] on a working age population. BMC Public Health 2011; 11: 612.
  19. Gibb A, Yang L.P. Olodaterol: first global approval. Drugs 2013; 73 (16): 1841-6.
  20. Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease. NHLBI/WHO workshop report updated 2015.
  21. Global Strategy for Asthma Management and Prevention (2015 update).
  22. Gross N.G. Anticholinergic therapy in chronic obstructive pulmonary disease. London: Franclin Scientific, 1993.
  23. Guyatt G.H Townsend M, Pugsley S.O et al. Bronchodilators in chronic airflow limitation. Effects on airway function, exercise capacity, and quality of life. Am Rev Respir Dis 1987; 135 (5): 1069-74.
  24. Hanania N.A, Feldman G, Zachgo W et al. The efficacy and safety of the novel long - acting b2-agonist vilanterol in patients with COPD: a randomized placebo - controlled trial. Chest 2012; 142 (1): 119-27.
  25. Jones T.R, Charette L, Garcia M.L, Kaczorowski G.J. Selective inhibition of relaxation of guinea - pig trachea by charybdotoxin, a potent Ca++-activated K+-channel inhibitor. J Pharmacol Exp Ther 1990; 255: 697-706.
  26. Kanniess F, Boulet L.P, Pierzchala W et al. Efficacy and safety of indacaterol, a new 24-h b2-agonist, in patients with asthma: a dose - ranging study. J Asthma 2008; 45: 887-92.
  27. Kempsford R, Norris V, Siederer S. Vilanterol trifenatate, a novel inhaled long - acting beta2-adrenoceptor agonist, is well tolerated in healthy subjects and demonstrates prolonged bronchodilation in subjects with asthma and COPD. Pulm Pharmacol Ther 2013; 26 (2): 256-64.
  28. Kew K.M, Dias S, Cates C.J. Long - acting inhaled therapy (beta - agonists, anticholinergics and steroids) for COPD: a network meta - analysis. Cochrane Database Syst Rev 2014; Issue 3: Art. No.: CD010844. doi: 10.1002/14651858. CD010844.pub2.
  29. Kew K.M, Evans D.J, Allison D.E, Boyter A.C. Long - acting muscarinic antagonists (LAMA) added to inhaled corticosteroids (ICS) versus addition of long - acting beta2-agonists (LABA) for adults with asthma. Cochrane Database Syst Rev 2015; 6: CD011438. doi: 10.1002/14651858.CD011438.pub2.
  30. Kornmann O, Dahl R, Centanni S et al. Once - daily indacaterol vs twice - daily salmeterol for COPD: a placebo controlled comparison. Eur Respir J 2011; 37: 273-9.
  31. Kuehn B.M. FDA offers advice to reduce risks of long - acting beta - agonists in asthma care. JAMA 2010; 303 (14): 1353-4.
  32. La Force C, Alexander M, Deckelmann R et al. Indacaterol provides sustained 24 h bronchodilation on once - daily dosing in asthma: a 7-day dose - ranging study. Allergy 2008; 63: 103-11.
  33. La Force C, Korenblat P, Osborne P et al. 24-hour bronchodilator efficacy of single doses of indacaterol in patients with persistent asthma: comparison with placebo and formoterol. Curr Med Res Opin 2009; 25: 2353-9.
  34. Lee T.A, Pickard A.S, Au D.H et al. Risk for death associated with medications for recently diagnosed chronic obstructive pulmonary disease. Ann Intern Med 2008; 149: 380-90.
  35. Lombardi D, Cuenoud B, Kramer S.D. Lipid membrane interactions of indacaterol and salmeterol: do they influence their pharmacological properties? Eur J Pharm Sci 2009; 38: 533- 47.
  36. Lopez A.D, Shibuya K, Rao C et al. Chronic obstructive pulmonary disease: current burden and future projections. Eur Respir J 2006; 27 (2): 397-412.
  37. Lotvall J, Bateman E.D, Bleecker E.R et al. 24h duration of the novel LABA vilanterol trifenatate in asthma patients treated with inhaled corticosteroids. Eur Respir J 2012; 40 (3): 570-9.
  38. Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 2004; 59: 469-78.
  39. Mathers C.D, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006; 3: e442.
  40. Meurs H. A new perspective on muscarinic receptor antagonism in obstructive airway disease. Curr Opin Pharmacol 2013; 13: 316-23.
  41. Mc Intyre E, Alpers J.H, Ruffin R.E. Bronchial smooth muscle tone in normal subjects. Chest 1982; 81 (3): 396.
  42. Mc Kay S.E, Howie C.A, Thomson A.H et al. Value of theophylline treatment in patients handicapped by chronic obstructive lung disease. Thorax 1993; 48 (3): 227-32.
  43. Murciano D, Auclair M.H, Pariente R, Aubier M. A randomized, controlled trial of theophylline in patients with severe chronic obstructive pulmonary disease. N Engl J Med 1989; 320 (23): 1521-5.
  44. Naline E, Trifilieff A, Fairhurst R.A et al. Effect of indacaterol, a novel long acting b2-agonist, on isolated human bronchi. Eur Respir J 2007; 29: 575-81.
  45. Pearlman D.S, Greos L, La Force C et al. Bronchodilator efficacy of indacaterol, a novel once - daily beta2-agonist, in patients with persistent asthma. Ann Allergy Asthma Immunol 2008; 101: 90-5.
  46. Procopiou P.A, Barrett V.J, Bevan N.J et al. Synthesis and structure - activity relationships of long - acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: an antedrug approach. J Med Chem 2010; 53 (11): 4522-30.
  47. Rosethorne E.M, Turner R.J, Fairhurst R.A, Charlton S.J. Efficacy is a contributing factor to the clinical onset of bronchodilation of inhaled b2-adrenoceptor agonists. Naunyn Schmiedebergs Arch Pharmacol 2010; 382: 255-63.
  48. Salpenter S.R, Buckley N.S, Salpenter E.E. Meta - analiysis: anticholinergics, but not b2-agonists, reduce severe exacerbations and respiratory mortality in COPD. J Gen Intern Med 2006; 21: 1011-9.
  49. Sharpe T.R, Mikeal R.L. Patient compliance with prescription medication regimens. J Am Pharm Assoc 1975; 15 (4): 191-2.
  50. Singh S, Loke Y.K, Furberg C.D. Inhaled anticholinergics and risk of major adverse cardiovascular events in patients with chronic obstructive pulmonary disease: a systematic review and meta - analysis. JAMA 2008; 300: 1439-50.
  51. Singh S, Loke Y.K, Enright P.L, Furberg C.D. Mortality associated with tiotropium mist inhaler in patients with chronic obstructive pulmonary disease: systematic review and meta - analysis of randomised controlled trials. BMJ 2011; 342: d3215.
  52. Singh S, Loke Y.K, Enright P, Furberg C.D. Pro - arrhythmic and pro - ischaemic effects of inhaled anticholinergic medications. Thorax 2013; 68 (1): 114-6.
  53. Sturton R.G, Trifilieff A, Nicholson A.G, Barnes P.J. Pharmacological characterization of indacaterol, a novel once daily inhaled _2 adrenoceptor agonist, on small airways in human and rat precision - cut lung slices. J Pharmacol Exp Ther 2008; 324: 270-5.
  54. Sugihara N, Kanada S, Haida M et al. 24-h bronchodilator efficacy of single doses of indacaterol in Japanese patients with asthma: A comparison with placebo and salmeterol. Respir Med 2010; 104: 1629-37.
  55. Tashkin D.P, Celli B, Senn S et al. UPLIFT Study Investigators. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med 2004; 359: 1543-54.
  56. Van den Boom G, Van Schayck C.P, Van Mollen M.P et al. Active detection of chronic obstructive pulmonary disease and asthma in the general population. Results and economic consequences of the DIMCA program. Am J Respir Crit Care Med 1998; 158: 1730-8.
  57. Van Noord J.A, Smeets J.J, Drenth B.M et al. 24Hour bronchodilation following a single dose of the novel β2agonist olodaterol in COPD. Pulm Pharmacol Ther 2011; 24: 666-72.
  58. Yang W.H, Martinot J.B, Pohunek P et al. Tolerability of indacaterol, a novel once - daily beta2-agonist, in patients with asthma: a randomized, placebo - controlled, 28-day safety study. Ann Allergy Asthma Immunol 2007; 99: 555-61.
  59. Zhou Y, Wang X, Zeng X et al. Positive benefits of theophylline in a randomized, double - blind, parallel group, placebo controlled study of low - dose, slow - release theophylline in the treatment of COPD for 1 year. Respirology 2006; 11 (5): 603-10.

Copyright (c) 2016 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies