Therapy of acute respiratory diseases with those operating under conditions of low intensity occupational hazards

Consistently high incidence of acute upper respiratory infections of multiple and unspecified localization, and significant economic losses induced by them dictate the need for the development of therapeutic and preventive measures against this pathology. The purpose of the study was to explore the therapeutic efficacy of the drug Kagocel and tolerance to it in the treatment of acute respiratory infections (ARI).Materials and methodology. Included in the observational study were 100 patients from 43 to 65 years of age, who received outpatient treatment with a confirmed diagnosis of ARI, whose working conditions featured low intensity occupational hazards, and who were taking Kagocel in combination with symptomatic therapy. The control group consisted of 50 patients of comparable age with an established diagnosis of acute respiratory disease receiving only symptomatic therapy on an outpatient basis. Evaluated were the efficacy of Kagocel and the tolerance to the drug. The results of observational studies were processed with the standard software package Statistica 8.0 (StatSoft, Inc., USA) using standard methods of comparative analysis and descriptive statistics.Results. The assessment of the treatment effectiveness revealed that the intoxication and catarrhal syndromes with patients taking Kagocel had been less pronounced already on day 3 of treatment, as compared to the group of patients receiving just symptomatic therapy. The analysis of additionally prescribed drugs showed that none of the patients in the main group was in need of being prescribed antimicrobial and mucolytic drugs, and the duration of taking symptomatic medications was 1.8±0.1 days. In the control group the average duration of receiving medications was 3.9±0.4 days (p<0.05), while 10.0 percent of the cases required administration of penicillins combined with mucolytics due to the complicated course of ARI. Also noted were good tolerance and lack of side effects in the course of treating ARI accompanied with the administration of Kagocel.Conclusions: 1. The results of the outpatient administration of the drug Kagocel in the treatment of ARI demonstrate high clinical efficiency of ARI therapy with Kagocel as the reference drug (as compared to symptomatic therapy). 2. Administration of Kagocel featured a more rapid relief of intoxication and catarrhal syndromes of the disease, resulting in the reduction in the need for symptomatic remedies and facilitating a quicker recovery (as compared to symptomatic therapeutic agents). 3. The inclusion of the drug Kagocel in the ARI treatment not only resulted in a more rapid control of the disease, but also prevented the development of complications. Patients of the main group taking Kagocel did not suffer from exacerbations of chronic bronchitis. 4. Kagocel proved to be tolerated well, and its use was not accompanied by complications or side effects.

acute respiratory diseases, inductors of interferons, Kagocel, operation under conditions of occupational hazards, the efficacy of ARI