A look at the effectiveness of the release of active antivirals in treatment of influenza and ARVI in the light of evidence-based medicine

The problem of treatment and prophylaxis of acute respiratory viral infections (ARVI) is interdisciplinary and covers medical, social and economic aspects. The high relevance of the problem is determined by the prevalence of infections themselves, high sensitivity to them patients of all age categories, a significant rate of complications and exacerbations of several chronic diseases, especially in patients at risk. The lack of specific methods of prevention and treatment of ARVI, its non-influenza etiology, limited range of drugs for antiviral therapy in this group of medicines determine the need for a thorough analysis of the efficacy and safety of existing drugs with the position of evidence-based medicine. Attention of authors was attracted by a group of innovative domestic antivirals, established on the basis of antibodies to interferon-g release in a human-active form. This work is carried out with the purpose of concentration and systematization of information on the results of the preclinical assessment of antiviral activity of Ergoferon, Anaferon Kids and Anaferon, as well as data from clinical studies of these drugs in acute respiratory viral infections in children and adults. It uses search-analytical method for processing information sources published in specialized medical journals and are freely available in printed and electronic form on the Internet. The work is a brief literature review, which presents evidence of antiviral activity of Ergoferon, Anaferon Kids and Anaferon, current understanding of the mechanism of action of drugs, based on the data of the complex scientific and experimental studies on the molecular level. Also, review the results of clinical trials, which, according to the authors, with a high degree of evidence demonstrating the therapeutic efficacy and Ergoferon, as well as Anaferon Kids in the treatment of ARVI. Proofs of comparability of treatment of the antiviral activity of these drugs with ostamyvirum during influenza treatment in children and adults.

Ergoferon, Anaferon Kids, Anaferon, influenza, ARVI therapy, prevention, interferon g