Placental insufficiency: features etiology and pathogenesis, therapy and prevention

Cover Page

Cite item

Full Text

Abstract

The article discusses the features of the etiology, pathogenesis, treatment options and prevention of placental insufficiency (PI) - one of the most common and the most important problems of modern obstetrics, characterized by changes in the structure and function of the placenta, and as a result - a violation of the growth and development of the fetus. Due to the fact that one of the leading pathogenetic mechanisms of PI are considered violations of uteroplacental and fetoplacental blood flow associated with endothelial dysfunction, deterioration of the rheological properties of blood, red blood cells and platelets hyperaggregation, microcirculatory disorders, violation of vascular tone, sound is the use of anticoagulants and antiplatelet agents .

About the authors

A. L Unanyan

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Email: 9603526@mail.ru
д-р мед. наук, проф. каф. акушерства и гинекологии №1 ГБОУ ВПО Первый МГМУ им. И.М.Сеченова 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

S. E Arakelov

People's Friendship University of Russia

Email: info@gp68.mosgorzdrav.ru
канд. мед. наук, доц. каф. акушерства и гинекологии РУДН, глав. врач ГП №68 117918, Russian Federation, Moscow, ul. Miklukho-Maklaia, d. 6

L. S Polonskaya

Clinical Hospital №53 of the Department of Health of Moscow

Email: ml.7951447@gmail.com
канд. мед. наук, зав. гинекологическим отд-нием ГКБ №53 115432, Russian Federation, Moscow, ul. Trofimova, d. 26

T. D Guriyev

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

д-р мед. наук, проф. каф. акушерства и гинекологии ИПО ГБОУ ВПО Первый МГМУ им. И.М.Сеченова 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

T. S Ilicheva

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

студентка лечебного фак-та ГБОУ ВПО Первый МГМУ им. И.М.Сеченова 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

D. V Baburin

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

ассистент каф. акушерства и гинекологии №1 ГБОУ ВПО Первый МГМУ им. И.М.Сеченова 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

Yu. M Kossovich

I.M.Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

аспирантка каф. акушерства и гинекологии №1 ГБОУ ВПО Первый МГМУ им. И.М.Сеченова 119991, Russian Federation, Moscow, ul. Trubetskaia, d. 8, str. 2

References

  1. Макацария А.Д., Бицадзе В.О., Акиньшина С.В. Тромбозы и тромбоэмболии в акушерско - гинекологической клинике. Молекулярно - генетические механизмы и стратегия профилактики тромбоэмболических осложнений. Руководство для врачей. М.: МИА, 2007.
  2. Петрухин В.А., Мельников А.П., Гришин В.Л. и др. Влияние препарата «Курантил» на состояние внутриплацентарного кровотока. Московский областной НИИ акушерства и гинекологии. Гинекология. 2007; 4.
  3. Серов В.Н., Тютюнник В.Л., Михайлова О.И. Современные представления о лечении плацентарной недостаточности. Рус. мед. журн. 2010; 18 (4): 157-62.
  4. Сидорова И.С., Макаров И.О. Клинико - диагностические аспекты фетолацентарной недостаточности. М.: МИА, 2005.
  5. Herrera E.A, Krause B, Ebensperger G et al. The placental pursuit for an adequate oxidant balance between the mother and the fetus. Front Pharmacol 2014; 5: 149; doi: 10.3389/fphar.2014.00149.
  6. Parker S.E, Werler M.M. Epidemiology of ischemic placental disease: a focus on preterm gestations. Semin Perinatol 2014; 38 (3): 133-8; doi: 10.1053/j.semperi.2014.03.004.
  7. Levy R.A, dos Santos F.C, de Jesús G.R, de Jesús N.R. Antiphospholipid Antibodies and Antiphospholipid Syndromeduring Pregnancy: Diagnostic Concepts. Front Immunol 2015; 6: 205; doi: 10.3389/fimmu.2015.00205. eCollection 2015. Review.
  8. Born G, Patrono C. Antiplatelet drugs. Br J Pharmacol 2006; 147 (Suppl. 1): S241-S251.
  9. Eikelboom J.W, Hirsh J, Spencer F.A et al. Antiplatelet drugs: Antithrombotic Therapy and Prevention of Thrombosis, 9thed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141 (Suppl. 2): e89S-119S; doi: 10.1378/chest.11-2293.
  10. Müller T.H, Su C.A, Weisenberger H et al. Dipyridamole alone or combined with low - dose acetylsalicylic acid inhibits platelet aggregation in human whole blood ex vivo. Br J Clin Pharmacol 1990; 30 (2): 179-86.
  11. Weyrich A.S, Denis M.M, Kuhlmann-Eyre J.R et al. Dipyridamole selectively inhibits inflammatory gene expression in platelet - monocyte aggregates. Circulation 2005; 111 (5): 633-42.
  12. Ciccone M.M, Cortese F, Corbo F et al. Bemiparin, an effective and safe low molecular weight heparin: a review. Vascul Pharmacol 2014; 62 (1): 32-7; doi: 10.1016/j.vph.2014.03.001. Epub 2014.
  13. Villa J, Marco A, Santamaria A et al. Service. Gynaecology and Obstetrics Department, Hospital de la Santa Creu I Sant Pau, Barcelona, Spain, 2006. Haemostasis and Thrombosis Unit, Haematology.
  14. Alalaf S.K. Bemiparin versus low dose aspirin for management of recurrent early pregnancy losses due to antiphospholipd antibody syndrome. Arch Gynecol Obstet 2012; 285 (3): 641-7; doi: 10.1007/s00404-011-2055-y. Epub 2011.
  15. Alalaf S.K, Jawad R.K, Muhammad P.R et al. Bemiparin versus enoxaparin as thromboprophylaxis following vaginal and abdominal deliveries: a prospective clinical trial. BMC Pregnancy Childbirth 2015; 15: 72; doi: 10.1186/s12884-015-0515-2.
  16. Cruz M, Fernández-Alonso A.M, Rodríguez I et al. Postcesarean thromboprophylaxis with two different regimens of bemiparin. Obstet Gynecol Int 2011; 2011: 548327. Epub 2011.

Copyright (c) 2015 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies