Difference of genetic polymorphisms in patients with type 2 diabetes mellitus with absence or presence of chronic heart failure with preserved ejection fraction
- Authors: Sveklina T.S.1, Shustov S.B.1, Kolyubaeva S.N.1, Kuchmin A.N.1, Kozlov V.A.2, Halimov Y.S.3, Konyaev V.V.1
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Affiliations:
- Kirov Military Medical Academy
- I.N. Ulyanov Chuvash State University
- Academician I.P. Pavlov First St. Petersburg State Medical University
- Issue: Vol 25, No 10 (2023): Болезни сердца и сосудов
- Pages: 693-697
- Section: Articles
- URL: https://journals.rcsi.science/2075-1753/article/view/251385
- DOI: https://doi.org/10.26442/20751753.2023.10.202308
- ID: 251385
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Abstract
Background. It is important to note a close comorbidity of type 2 diabetes mellitus (DM2) and cardiovascular issues, in particular, chronic heart failure (CHF) among the elderly patients. Research of predisposing genes’ polymorphisms allows to connect genotype particularities with the development of such conditions.
Aim. Identify genetic polymorphisms in patients with DM2 and CHF with preserved ejection fraction.
Materials and methods. Polymorphisms of genes of folate cycle, metabolism, hemostasis, neurohumoral status were studied in 106 patients (age 69.7±10.1 years) with DM2 and hypertension with and without CHF.
Results. In patients with DM2 without CHF, the frequency of polymorphisms of these genes is comparable to the population. There are MTHFR: 677 C>T, MTR: A2756G, ITGB3: T1565C, PAI-1: -675 5G>4G, NOS3: -786 T>C, PPARG: C1431T was found in patients with DM2 and CHF, a statistically significant increase in the frequency of gene polymorphisms was found, compared with patients with DM2 without CHF.
Conclusion. The identified polymorphisms in patients with type 2 diabetes and CHF with preserved LV ejection fraction are associated with such phenotypic manifestations as: a tendency to thrombophilia, realized through a violation of homocysteine, vascular tone and trophism, immune response, as well as the oxidation of free fatty acids and the activation of the inflammation process.
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##article.viewOnOriginalSite##About the authors
Tatiana S. Sveklina
Kirov Military Medical Academy
Author for correspondence.
Email: Sveklinats@mail.ru
ORCID iD: 0000-0001-9546-7049
Cand. Sci. (Med.), Assoc. Prof.
Russian Federation, St. PetersburgSergey B. Shustov
Kirov Military Medical Academy
Email: editor@omnidoctor.ru
ORCID iD: 0000-0002-9075-8274
D. Sci. (Med.), Prof.
Russian Federation, St. PetersburgSvetlana N. Kolyubaeva
Kirov Military Medical Academy
Email: editor@omnidoctor.ru
ORCID iD: 0000-0003-2441-9394
D. Sci. (Biol.)
Russian Federation, St. PetersburgAlexei N. Kuchmin
Kirov Military Medical Academy
Email: editor@omnidoctor.ru
ORCID iD: 0000-0003-2888-9625
D. Sci. (Med.), Prof.
Russian Federation, St. PetersburgVadim A. Kozlov
I.N. Ulyanov Chuvash State University
Email: editor@omnidoctor.ru
ORCID iD: 0000-0001-7488-1240
D. Sci. (Biol.), Cand. Sci. (Med.)
Russian Federation, CheboksaryYrii Sh. Halimov
Academician I.P. Pavlov First St. Petersburg State Medical University
Email: editor@omnidoctor.ru
ORCID iD: 0000-0002-7755-7275
D. Sci. (Med.), Prof.
Russian Federation, Saint PetersburgVladislav V. Konyaev
Kirov Military Medical Academy
Email: editor@omnidoctor.ru
Student
Russian Federation, St. PetersburgReferences
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