Tongue cancer in a patient with pulmonary tuberculosis. Case report
- Authors: Kulchavenya E.V.1,2, Myshkova E.P.1, Dementieva E.I.1, Baranchukova A.A.2
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Affiliations:
- Novosibirsk Tuberculosis Research Institute
- Novosibirsk State Medical University
- Issue: Vol 23, No 12 (2021)
- Pages: 982-985
- Section: Articles
- URL: https://journals.rcsi.science/2075-1753/article/view/100039
- DOI: https://doi.org/10.26442/20751753.2021.12.201288
- ID: 100039
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Abstract
Tuberculosis and malignant neoplasms are a global threat, these diseases claim millions of lives and cause tremendous suffering to people worldwide. Tuberculosis can mask cancer and create preconditions for carcinogenesis. The article presents a clinical case of tongue cancer in a patient with pulmonary tuberculosis. Patient B.N., 45 years old, was admitted to the FSBI “Novosibirsk Tuberculosis Research Institute” with complaints of a "sore place" on the tongue, pain in the right half of the tongue, enlargement of the submandibular lymph nodes on the right The tongue hurts for about 1,5 years, but over the last 2 months, condition has worsened. The patient noticed an increase in the size of lesion on the tongue and increased pain, especially during meals (he can eat only after pain relief, for which he takes Nimesulide 4 pills a day). In recent days, he felt also epigastric pain for which he didn’t visit a doctor. Tongue biopsy was performed, and histological analysis revealed cancer. The patient was diagnosed with fibrous-cavernous tuberculosis of the upper lobe of the right lung, infiltration and seeding phase; mycobacterium tuberculosis (+); broad drug resistance (HRSECmKmPasCsOfl); gastric ulcer (0,5 cm), exacerbation stage; chronic erosive gastritis, exacerbation stage; malignant neoplasm of the floor of the mouth on the right T3(4)N1M1. With this diagnosis, the patient was discharged for further treatment by oncologists. Physicians need to have a high alertness for cancer in patients with tuberculosis, especially those in the high-risk group. A minimum of standard diagnostic procedures will allow you to verify the diagnosis timely.
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##article.viewOnOriginalSite##About the authors
Ekaterina V. Kulchavenya
Novosibirsk Tuberculosis Research Institute; Novosibirsk State Medical University
Author for correspondence.
Email: urotub@yandex.ru
ORCID iD: 0000-0001-8062-7775
D. Sci. (Med.), Prof.
Russian Federation, Novosibirsk; NovosibirskElena P. Myshkova
Novosibirsk Tuberculosis Research Institute
Email: urotub@yandex.ru
ORCID iD: 0000-0002-3884-938X
Department Head
Russian Federation, NovosibirskEkaterina I. Dementieva
Novosibirsk Tuberculosis Research Institute
Email: urotub@yandex.ru
ORCID iD: 0000-0003-0372-8876
phthisiologist
Russian Federation, NovosibirskAnzhelika A. Baranchukova
Novosibirsk State Medical University
Email: koshka.70@mail.ru
ORCID iD: 0000-0003-4560-1611
Cand. Sci. (Med.)
Russian Federation, NovosibirskReferences
- Falagas ME, Kouranos VD, Athanassa Z, Kopterides P. Tuberculosis and malignancy. QJM. 2010;103(7):461-87. doi: 10.1093/qjmed/hcq068
- Kulchavenya E, Naber K, Bjerklund Johansen TE. Urogenital tuberculosis: classification, diagnosis, and treatment. European Urology Supplement. 2016;15(4):112-21. doi: 10.1016/j.eursup.2016.04.001
- Кульчавеня Е.В., Жукова И.И. Внелегочный туберкулез – вопросов больше, чем ответов. Туберкулез и болезни легких. 2017;95(2):59-63 [Kulchavenya EV, Zhukova II. Extrapulmonary tuberculosis – more questions than answers. Tuberculosis and Lung Disease. 2017;95(2):59-63 (in Russian)]. doi: 10.21292/2075-1230-2017-95-2-59-63
- Fragoso J, Oliveira MM, Gonçalves C, et al. Oral ulcer as presentation of cavitating pulmonary tuberculosis. IDCases. 2020;22:e00976. doi: 10.1016/j.idcr.2020.e00976
- Kim SY, Byun JS, Choi JK, Jung JK. A case report of a tongue ulcer presented as the first sign of occult tuberculosis. BMC Oral Health. 2019;19(1):67. doi: 10.1186/s12903-019-0764-y
- Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-49. doi: 10.3322/caac.21660
- Spector ME, Bellile E, Amlani L, et al.; University of Michigan Head and Neck SPORE Program. Prognostic Value of Tumor-Infiltrating Lymphocytes in Head and Neck Squamous Cell Carcinoma. JAMA Otolaryngol Head Neck Surg. 2019;145(11):1012-9. doi: 10.1001/jamaoto.2019.2427
- Moore SR, Johnson NW, Pierce AM, Wilson DF. The epidemiology of tongue cancer: a review of global incidence. Oral Dis. 2000;6(2):75-84. doi: 10.1111/j.1601-0825.2000.tb00105.x
- Злокачественные новообразования в России в 2016 году (заболеваемость и смертность). Под ред. А.Д. Каприна, В.В. Старинского, Г.В. Петровой. М.: МНИОИ им. П.А. Герцена – филиал ФГБУ «НМИЦ радиологии» Минздрава России, 2018 [Zlokachestvennye novoobrazovaniia v Rossii v 2016 godu (zabolevaemost' i smertnost'). Pod red. AD Kaprina, VV Starinskogo, GV Petrovoi. Moscow: MNIOI im. P.A. Gertsena – filial FGBU “NMITs radiologii” Minzdrava Rossii, 2018 (in Russian)].
- Bello IO, Soini Y, Salo T. Prognostic evaluation of oral tongue cancer: means, markers and perspectives (II). Oral Oncol. 2010;46(9):636-43. doi: 10.1016/j.oraloncology.2010.06.008
- Mäkinen LK, Hagström J, Mäkitie A, Atula T. Cancer of the tongue – early detection improves the prognosis. Duodecim. 2016;132(22):2063-70.
- Vered M, Dayan D. Tongue cancer: an ongoing problem which needs new therapeutic approaches. Harefuah. 2013;152(6):352-5, 368, 367 (In Hebrew).
- Papageorge MB. Etiology of oral cancer in the young patient: is tongue cancer becoming the other cancer in women? Oral Maxillofac Surg Clin North Am. 2007;19(2):163-71, v. doi: 10.1016/j.coms.2007.01.004
- Nanthanangkul S, Promthet S, Suwanrungruang K, et al. Incidence of and Risk Factors for Tuberculosis among Cancer Patients in Endemic Area: A Regional Cohort Study. Asian Pac J Cancer Prev. 2020;21(9):2715-21. doi: 10.31557/APJCP.2020.21.9.2715
- Bickett TE, Karam SD. Tuberculosis-Cancer Parallels in Immune Response Regulation. Int J Mol Sci. 2020;21(17):6136. doi: 10.3390/ijms21176136
- Simonsen DF, Farkas DK, Søgaard M, et al. Tuberculosis and risk of cancer: a Danish nationwide cohort study. Int J Tuberc Lung Dis. 2014;18(10):1211-9. doi: 10.5588/ijtld.14.0161
- Cocito C, Maes H. Immunological relatedness of the protective mechanisms against tuberculosis and cancer. Eur J Clin Invest. 1998;28(1):1-12. doi: 10.1046/j.1365-2362.1998.00248.x