Surface-active properties and physiological activity of systems chitosan succinamide–surface-active substance

Abstract

The effect of water-soluble polymer—chitosan succinamide—on surface activity of such commonly used surfactants as anionic sodium dodecylsulfate and nonionic TWEEN-80 is investigated. It is shown that the combined use of sodium dodecylsulfate and TWEEN-80 with chitosan succinamide increases the surface activity of the investigated surfactants. It is found that the association of chitosan succinamide with sodium dodecylsulfate or TWEEN-80 begins at concentrations an order of magnitude lower than the critical micelle concentration of studied surfactants. The fact of reduction in the dynamic viscosity of the solution of chitosan succinamide in the presence of both ionic and nonionic surfactants, apparently owing to the formation of polymer-colloid complexes, is revealed. The obtained systems have a stabilizing effect on the membrane of red blood cells in stringent hypotonic conditions, which may indicate a decrease in the adverse effect of surfactants on the skin.