Investigation of physicochemical and biological properties of composite matrices in a alginate–calcium phosphate system intended for use in prototyping technologies during replacement of bone defects

V. S. Komlev; N. S. Sergeeva; A. Yu. Fedotov; I. K. Sviridova; V. A. Kirsanova; S. A. Akhmedova; A. Yu. Teterina; Yu. V. Zobkov; E. A. Kuvshinova; Ya. D. Shanskiy; S. M. Barinov

doi:10.1134/S2075113316040158

Investigation of physicochemical and biological properties of composite matrices in a alginate–calcium phosphate system intended for use in prototyping technologies during replacement of bone defects

Authors: Komlev V.S.¹, Sergeeva N.S.², Fedotov A.Y.¹, Sviridova I.K.², Kirsanova V.A.², Akhmedova S.A.², Teterina A.Y.¹, Zobkov Y.V.¹, Kuvshinova E.A.², Shanskiy Y.D.², Barinov S.M.¹
Affiliations:
1. Baikov Institute of Metallurgy and Materials Science
2. Medical Radiological Research Centre of the Ministry of Health
Issue: Vol 7, No 4 (2016)
Pages: 630-634
Section: Article
URL: https://journals.rcsi.science/2075-1133/article/view/205602
DOI: https://doi.org/10.1134/S2075113316040158
ID: 205602

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Abstract

Materials for 3D printing of porous composite materials (CM) that are based on sodium alginate–tricalcium phosphate are developed. Physicochemical and biological studies of CM in vitro are performed using a model of two adherent cells lines, immortalized human fibroblasts (HF, strain 1608h TERT) and human osteosarcoma (MG-63) that are cultivated up to 21 days. The cytocompatibility and matrix properties are studied by an MTT assay.