Genetic variations of morphine transporters: prevalence of polymorphisms of the ABCB1 gene among oncology patients of palliative profile
- 作者: Khaitovich E.D.1, Shikh E.V.1, Ibragimov A.N.2, Gergel M.A.2, Borisov A.S.2, Kazakov R.E.3
-
隶属关系:
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- Moscow Multidisciplinary Center for Palliative Care, Moscow Healthcare Department
- Scientific Center for Expertise of Medical Products
- 期: 卷 32, 编号 6 (2025)
- 页面: 182-188
- 栏目: Oncology
- URL: https://journals.rcsi.science/2073-4034/article/view/350659
- DOI: https://doi.org/10.18565/pharmateca.2025.6.182-188
- ID: 350659
如何引用文章
开放存取
##reader.subscriptionAccessGranted##
订阅存取
详细
Objective: Assessment of the prevalence of clinically significant single nucleotide polymorphisms of the ABCB1 gene (rs1128503, rs2032582, rs1045642) in palliative cancer patients receiving morphine in order to substantiate the prospects of a pharmacogenetic approach to personalized analgesic therapy.
Materials and methods: The study included 86 patients with cancer in the palliative stage and receiving morphine, as well as 100 control patients without cancer. Genotyping of ABCB1 polymorphisms was performed using real-time polymerase chain reaction. The dynamics of pain syndrome was also assessed using a visual analog scale (VAS) at three stages of therapy.
Results: A high frequency of heterozygous CT variants for rs1128503 and rs1045642 polymorphisms was established. VAS analysis showed a decrease in pain syndrome from 8 to 2 points after the start of morphine therapy, which confirms its effectiveness.
Conclusion: ABCB1 gene polymorphisms may play a significant role in the variability of response to morphine in cancer patients. The obtained data emphasize the need for further research to develop personalized pain relief strategies taking into account genetic characteristics.
作者简介
Evgeny Khaitovich
I.M. Sechenov First Moscow State Medical University (Sechenov University)
编辑信件的主要联系方式.
Email: eukhad@gmail.com
ORCID iD: 0000-0003-2629-9250
Postgraduate Student, Department of Clinical Pharmacology and Propaedeutics of Internal Medicine, Clinical Pharmacologist
俄罗斯联邦, MoscowEvgenia Shikh
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: chih@mail.ru
ORCID iD: 0000-0001-6589-7654
Dr. Sci. (Med.), Professor, Corr. Member of the RAS, Head of the Department of Clinical Pharmacology and Propaedeutics of Internal Medicine
俄罗斯联邦, MoscowArif Ibragimov
Moscow Multidisciplinary Center for Palliative Care, Moscow Healthcare Department
Email: eukhad@gmail.com
Chief Physician
俄罗斯联邦, MoscowMark Gergel
Moscow Multidisciplinary Center for Palliative Care, Moscow Healthcare Department
Email: eukhad@gmail.com
Palliative Care Physician
俄罗斯联邦, MoscowAnton Borisov
Moscow Multidisciplinary Center for Palliative Care, Moscow Healthcare Department
Email: eukhad@gmail.com
Palliative Care Physician
俄罗斯联邦, MoscowRuslan Kazakov
Scientific Center for Expertise of Medical Products
Email: eukhad@gmail.com
ORCID iD: 0000-0003-0802-4229
Cand. Sci. (Biol.), Leading Researcher
俄罗斯联邦, Moscow参考
- Lin J.H., Yamazaki M. Role of P-glycoprotein in pharmacokinetics: clinical implications. Clin Pharmacokinet. 2003;42(1):59–98. https://dx.doi.org/10.2165/00003088-200342010-00003
- Tanabe M., Ieiri I., Nagata N., et al. Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene. J Pharmacol Exp Ther. 2001;297(3):1137–43.
- Schaeffeler E., Eichelbaum M., Brinkmann U., et al. Frequency of C3435T polymorphism of MDR1 gene in African people. Lancet. 2001;358(9279):383–4. https://dx.doi.org/10.1016/S0140-6736(01)05579-9
- Zhou Z., Chen Q., Zuo D., et al. ABCB1 (rs1128503) polymorphism and response to chemotherapy in patients with malignant tumors-evidences from a meta-analysis. Int J Clin Exp Med. 2015;8(1):265–72.
- Rychlik-Sych M., Barańska M., Dudarewicz M., et al. Haplotypes of ABCB1 1236C >T (rs1128503), 2677G >T/A (rs2032582), and 3435C >T (rs1045642) in patients with bullous pemphigoid. Arch Dermatol Res. 2018;310(6):515–22. https://dx.doi.org/10.1007/s00403-018-1842-8
- Клинические рекомендации. Хронический болевой синдром (ХБС) у взрослых пациентов, нуждающихся в паллиативной медицинской помощи. 2023-2024-2025 (15.02.2023). [Clinical guidelines. Chronic pain syndrome (CPS) in adult patients requiring palliative care. 2023-2024-2025 (15.02.2023). (In Russ.)].
- Хайтович Е.Д., Ших Е.В., Ибрагимов А.Н. и др. Полиморфизм рецепторных и ферментативных генов, ассоциированных с выраженностью анальгетического эффекта морфина у онкологических пациентов паллиативного профиля. Фармакология & Фармакотерапия. 2025;1:42–8. [Khaitovich E.D., Shikh E.V., Ibragimov A.N. et al. Polymorphism of receptor and enzymatic genes associated with the severity of the analgesic effect of morphine in palliative cancer patients. Pharmacology & Pharmacotherapy. 2025;1:42–8. (In Russ.)]. https://dx.doi.org/10.46393/27132129_2025_1_42–48
- Когония Л.М., Волошин В.Г., Когония Л.М. и др. Практические рекомендации по лечению хронического болевого синдрома у онкологических больных. Злокачественные опухоли. 2016;4(Спецвыпуск 2)):474–85. [Kogoniya L.M., Voloshin V.G., Kogoniya L.M. et al. Practical guidelines for the treatment of chronic pain syndrome in cancer patients. Malignant tumors. 2016;4(Special issue 2)):474–85. (In Russ.)].
- Ziegler L., Mulvey M., Blenkinsopp A., et al. Opioid prescribing for patients with cancer in the last year of life: A longitudinal population cohort study. Pain. 2016;157(11):2445–51. https://dx.doi.org/10.1097/j.pain.0000000000000656
- Ross J.R., Riley J., Taegetmeyer A.B., et al. Genetic variation and response to morphine in cancer patients: Catechol-O-methyltransferase and multidrug resistance-1 gene polymorphisms are associated with central side effects. Cancer. 2008;112(6):1390–403. https://dx.doi.org/10.1002/cncr.23292
补充文件
