Possibilities of presarcopenia and sarcopenia prevention in the face using synchronized radiofrequency technology and High-Intensity Facial Electrical Stimulation (HIFES)
- Authors: Svechnikova E.V.1,2, Morzhanaeva M.A.3, Artemyeva N.O.4
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Affiliations:
- Polyclinic №1 of the Administrative Directorate of the President of the Russian Federation
- Russian Biotechnology University
- BTL LLC
- Expert Multidisciplinary Clinic OMNIUS
- Issue: Vol 32, No 5 (2025)
- Pages: 80-93
- Section: Original articles
- URL: https://journals.rcsi.science/2073-4034/article/view/316497
- DOI: https://doi.org/10.18565/pharmateca.2025.5.80-93
- ID: 316497
Cite item
Abstract
Background: Sarcopenia, characterized by a progressive loss of skeletal muscle mass and strength, is a significant problem for the elderly, leading to a decrease in the quality of life and increased risk of falls and disability (EWGSOP, 2018). Despite the existing diagnostic criteria and assessment methods, gaps remain in the understanding of genetic and epigenetic factors that contribute to the development of preservation, which emphasizes the need for further research in this area.
Objective: to study the genetic and phenotypic predisposition to preservation and early sarcopenia in women aged 35–55 years, including with signs of undifferentiated connective tissue dysplasia (NDST) and evaluate the capabilities of the combined methodology of synchronized monopolar RF-lifting and electric field of high voltage (HIFES) as a prevention and the prevention and quality Correction of age -related changes at different types of aging.
Materials and methods: 36 women aged 35–55 years are included in pilot research. All patients were performed: an assessment of the composition of the body using bioimpedansometry (phase angle, active cell mass), cystic dynamometry, spirometry (Fjel, OFV1), molecular genetic tests (RS1800012_COL1A1, RS1800255_COL3A1, RS7787362_LN, RS1799750_MMP1) and used SARC-F1 and Face-Q questionnaires, a questionnaire to identify signs of NDST.
Results: Among 36 women aged 35–55 years with signs of violations in the synthesis and decay of collagen and elastin, satisfaction after the Emface procedures was clinically significant in patients with muscle type of aging. Dynamometry revealed a statistically significant decrease in the compression force of a brush in a group with signs of NDST (p=0,001). Genetic analysis showed that 89% of patients with signs of NDST had the polymorphism of the RS1800255_COL3A1 gene, which is much higher than in the control group (р<0,001). The SARC-F1 questionnaire demonstrated low sensitivity, emphasizing the need to create new screening profiles.
Conclusions: As a result of the study, an assessment of the development of preservation and sarcopenia in patients with and without and without. The discovered associations between the signs and the diagnostic capabilities of evaluating the risk of sarcopenia (bioimedance, dynamometry, spirituality and screening questionnaire to detect a predisposition to undifferentiated connective tissue dysplasia (NDST)) emphasize the expediency of the individualized approach, which includes a molecular genetic Diagnostics. The combined EMFACE methodology is potentially applicable as part of preventive programs, however, to confirm its contribution to the prevention of sarcrophy development, controlled studies are required for a long period of observation.
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##article.viewOnOriginalSite##About the authors
Elena V. Svechnikova
Polyclinic №1 of the Administrative Directorate of the President of the Russian Federation; Russian Biotechnology University
Author for correspondence.
Email: elene-elene@bk.ru
ORCID iD: 0000-0002-5885-4872
Dr. Sci. (Med.), Head of the Department of Dermatovenereology and Cosmetology; Professor of the Department of Skin and Venereal Diseases
Russian Federation, Moscow; MoscowMaria A. Morzhanaeva
BTL LLC
Email: maria_morzhanaeva@mail.ru
ORCID iD: 0000-0001-8657-9559
Cand. Sci. (Med.), Cosmetologist, Expert in the Development of Aesthetics
Russian Federation, MoscowNatalya O. Artemyeva
Expert Multidisciplinary Clinic OMNIUS
Email: natalya.artemeva.89@mail.ru
ORCID iD: 0000-0002-5619-6757
Sci. (Med.), Nutritionist, Geneticist
Russian Federation, MoscowReferences
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