On the problem of metatheoretical narratives of the foundations of bioethical assessment in the context of the development of gene therapy and gene diagnostics

Ethical assessment of biotechnology – genetic engineering, genetic medicine and gene diagnostics, is associated with the need for initial metathetical grounds for the implementation of assessment procedures. development of accurate, individualized and effective therapeutic approaches. On the other hand, the conventionality of existing concepts of morality allows us to turn to the principles of the systemic nature of being as ontological grounds for the implementation of ethical assessment of technologies as, perhaps, a conceptual renewal of theoretical and practical bioethics. The failure to create a general theoretical paradigm of morality allows, as an initial idea of methodological consideration and subsequent analysis, to consider the general ideological principles of the formation of value-based general cultural narratives. As such, first of all, the principles of orderliness and “mutual protection” of the elements of the system of being are taken, which can also be applied to the ethical issues of gene therapy, in the process of which there is an intervention in the genetic material of a person. Based on these ontological foundations, it is necessary to clearly distinguish between therapeutic goals aimed at treating diseases and attempts to purposefully change human nature in order to avoid turning science into an instrument of social control. The inclusion of such technologies in practical use requires strict control and the development of ethical protocols that would protect human dignity and rights, and the need for the principle of limitation as a fundamental principle on which the procedures for the ethical assessment of new biotechnologies can be built is realized. The article highlights two main principles that can be considered as objectively existing ethical narratives based on the ontological arguments of morality: the principle of maintaining the integrity of the system and the principle of limitation. At the same time, these principles show a large degree of unity with each other. Based on the presented arguments, it can be concluded that gene therapy, despite its enormous potential, requires extreme caution in its application.