Using of transdermal therapeutic system Durogesic® for acute postoperative pain therapy in patients after craniotomy


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Narcotic analgesics are the most powerful tool in the treatment of acute postoperative pain. The use of opioids is associated with risk of the development of potential side effects, which are particularly dangerous in the practice of neurosurgery clinic. The goal of this study was to compare the effectiveness of TTS Durogesic-matrix and NSAIDs used at the request for therapy of acute postoperative pain after craniotomy. We also assessed the effect of transdermal fentanyl on respiratory system during the perioperative period. Materials and methods: The study included 150 patients undergoing elective craniotomy for brain tu,or removal. NSAIDs used in the postoperative period on demand. Durogesik - matrix of 25 μg/h was set on the patient’s skin in advance. Postoperative pain was assessed using the visual analogue scale (VAS) at 6, 18, 30, 42, and 54 hours after surgery. Prolonged pulse oximetry monitoring of the patient’s natural sleeping was used to control the respiratory function during fentanil application and a day after transdermal system removal. Results: There was significant difference in the pain level on all stages of the study depend on the applied scheme of therapy. Pulse oximetry monitoring did not reveal depressive effects Durogesik - matrix of 25 μg/h on respiratory function. Conclusion: Use of transdermal fentanyl is much more effective and safer than NSAIDs used on demand in patients after craniotomy

作者简介

Aleksandr Imaev

FSBI “Burdenko Scientific Research Neurosurgery Institute”, FASO

Email: aimaev@nsi.ru
125047, Moscow

E. Dolmatova

Massachusetts General Hospital

Boston, MA 02114-2622, USA

A. Kulikov

FSBI “Burdenko Scientific Research Neurosurgery Institute”, FASO

125047, Moscow

A. Lubnin

FSBI “Burdenko Scientific Research Neurosurgery Institute”, FASO

125047, Moscow

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