Intensive therapy systemic toxicity of local anesthetics (clinical guidelines)


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Abstract

Development of the systemic toxicity of local anesthetics can quickly lead to severe bradycardia and hypotension, up to cardiac arrest. The presented clinical recommendations designed to optimize medical care and are included in the list of mandatory clinical protocols according to the Helsinki Declaration on Patient Safety in Anaesthesiology. This review summarizes the main mechanisms of toxicity when using local anesthetics. The guidelines set out criteria and signs of systemic toxicity, recommendations for its prevention. The algorithm of action and recommended dosage of drugs. An intensive care protocol systemic toxicity of local anesthetics including the use of lipid emulsion.

About the authors

Roman E. Lakhin

Military Medical Academy named after S.M. Kirov of the Ministry of Defense of RF

Email: doctor-lahin@yandex.ru
MD, PhD, DSc., docent of department of anesthesiology and critical care medicine, Military Medical Academy named after S.M. Kirov of the Ministry of Defense of the Russian Federation 194044, Saint-Petersburg

V. A Koryachkin

R.R. Vreden Russian Research Institute of Traumatology and Orthopedics

195427, Saint-Petersburg

D. N Uvarov

Northern State Medical University

163000, Arkhangelsk

G. E Ulrikh

St. Petersburg State Pediatric Medical University

194100, Saint-Petersburg

E. M Shifman

M.F. Vladimirsky Moscow Regional Research Clinical Institute

129110,Moscow

V. A Gluschenko

First Saint-Petersburg State Medical University named after. I.P. Pavlov, MH of RF

197022, Saint-Petersburg

A. V Kulikov

Ural State Medical Academy, MH of RF

620028, Yekaterinburg

References

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