The polymorphism of cathechol-O-methyltransferase gene and pain


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Abstract

The catechol-O-methyltrasferase (COMT) enzyme is involved in metabolism of dopamine, noradrenalin, adrenalin regulating such important physiologic functions as attitude, cognition and response to stress or pain. The gene encoding the COMP has functional polymorphisms that contribute to individual differences of human pain phenotype such as pain threshold, pain sensitivity, chronization of pain and response to analgesics. The review summarizes the results of genetic studies of COMT gene functional polymorphisms and their effect on pain phenomenon. The knowledge about mechanisms of gene COMT polymorphism effects allows to personalize treatment of pain of different genesis.

About the authors

Arina P. Spasova

Petrozavodsk State University

Email: arina22@mail.ru
MD, PhD, Assistant Professor of Chair of X-Ray diagnostic and X-Ray treatment with course of Critical And Respiratory Medicine of Medical Institution of Petrozavodsk State University Petrozavodsk, 185910, Russian Federation

O. Y Barysheva

Petrozavodsk State University

Medical Institution Petrozavodsk, 185910, Russian Federation

G. P Tikhova

Petrozavodsk State University

Medical Institution Petrozavodsk, 185910, Russian Federation

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