Полиморфизм гена катехол-О-метилтрансферазы и боль


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Аннотация

Фермент катехол-О-метилтрансфераза (COMT) участвует в метаболизме дофамина, норадреналина, адреналина, регулирующих такие важные физиологические функции, как настроение, познание, ответ на стресс и реакцию на боль. Ген, кодирующий фермент COMT, имеет функциональные полиморфизмы, которые вносят вклад в индивидуальные различия болевого фенотипа человека, такие как болевой порог, интенсивность болевого ощущения, хронизация болевого синдрома и реакция на анальгетики. В обзоре суммированы результаты генетических исследований функциональных полиморфизмов гена COMT и их влияние на феномен боли. Изучение механизмов влияния полиморфизма гена COMT позволит персонифицировать лечение болевых синдромов различного генеза.

Об авторах

Арина Павловна Спасова

ФГБОУ «Петрозаводский государственный университет» Министерства образования и науки РФ

Email: arina22@mail.ru
кандидат медицинских наук, доцент кафедры лучевой диагностики и лучевой терапии с курсом критической и респираторной медицины Медицинского института ФГБОУ «Петрозаводский государственный университет» Министерства образования и науки РФ 185910, Петрозаводск

О. Ю Барышева

ФГБОУ «Петрозаводский государственный университет» Министерства образования и науки РФ

Медицинский институт 185910, Петрозаводск

Г. П Тихова

ФГБОУ «Петрозаводский государственный университет» Министерства образования и науки РФ

Медицинский институт 185910, Петрозаводск

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