Postoperative analgesia with nephopam hydrochloride in plastic surgery


Cite item

Full Text

Abstract

The prospective clinical study was conducted in 150 female patients in early postoperative period after plastic and aesthetic surgeries. The analgesic effect and tolerability of nefopam hydrochloride within first hours following the surgery were evaluated. Nefopam hydrochloride was found to be a safe and useful adjunct to therapy for mild and moderate pain after plastic surgeries. Intramuscular injection of nefopam was associated with hemodynamic effects such as tachycardia and high blood pressure. These side effects should be accounted in postoperative pain management in patients with heart rate disorders, coronary heart disease, and hypertension.

About the authors

V. V. Kuzmin

Cosmetology and plastic surgery Center

Yekaterinburg

References

  1. Горобец Е. С. Концепция мультимодальной комбинированной анестезии и безопасность травматичных операций // Регионарная анестезия и лечение острой боли. 2009; 3(1): 39-45.
  2. Полушин Ю. С., Вартанова И. В., Беженарь В. Ф., Коростелев Ю. М., Голубь И. В. Оценка эффективности сочетанного применения нефопама гидрохлорида и кетопрофена в лечении послеоперационного болевого синдрома у больных эндометриозом // Журнал акушерства и женских болезней. 2012; 61(6): 48-53.
  3. Овечкин А. М., Романова Т. Л. Послеоперационное обезболивание: оптимизация подходов с точки зрения доказательной медицины. РМЖ. 2006; 14(12): 865-872.
  4. Овечкин А. М. Роль и место нефопама (акупана") в схеме мультимодальной анальгезии (обзор литературы) // Регионарная анестезия и лечение острой боли. 2011; 5(4): 5-12.
  5. Beloeil H., Delage N., Negre I. Mazoit J. X., Benhamou D. The median effective dose of nefopam and morphine administered intravenously for postoperative pain after minor surgery: a prospective randomized double-blind isobolographic study of their analgesic action // Anesth. Analg. 2004; 98(2): 395-400.
  6. Blaicher A. M., Landsteiner H. T., Al-Falaki O., Zwerina J., Volf I., Gruber D. [et al.] Acetylsalicylic acid, diclofenac, and lornoxicam, but not rofecoxib, affect platelet CD 62 expression // Anesth. Analg. 2004; 98(4): 1082-1085.
  7. Chanques G., Sebbane M., Constantin J. M., Ramillon N., Jung B., Cisse M. [et al.] Analgesic efficacy and haemodynamic effects of nefopam in critically ill patients // Br. J. Anaesth. 2011; 106(3): 336-343.
  8. Delage N., Maaliki H., Beloeil H., Benhamou D., Mazoit J. X. Median effective dose (ED50) of nefopam and ketoprofen in postoperative patients: a study of interaction using sequential and isobolographic analysis // Anesthesiology 2005; 102(6): 1211-1216.
  9. De Oliveira G. S. Jr, Agarwal D, Benzon H. T. Perioperative single dose ketorolac to prevent postoperative pain: a meta-analysis of randomized trials // Anesth Analg. 2012; 114(2): 424-433.
  10. Durrieu G., Olivier P., Bagheri H., Montastruc J. L. Overview of adverse reactions to nefopam: an analysis of the French Pharmacovigilance database // Fundam Clin Pharmacol. 2007; 21(5): 555-558.
  11. Du Manoir B., Aubrun F., Langlois M., Le Guern M. E., Alquier C., Chauvin M. [et al.] Randomized prospective study of the analgesic effect of nefopam after orthopaedic surgery // Br. J. Anaesth. 2003; 91(6): 836-841.
  12. Evans M. S., Lysakowski C., Tramer M. R. Nefopam for the prevention of postoperative pain: quantitative systematic review // Br. J. Anaesth. 2008; 101(5): 610-617.
  13. Forrest J. B, Camu F., Greer I. A., Kehlet H., Abdalla M., Bonnet F. [et al.] Ketorolac, diclofenac, and ketoprofen are equally safe for pain relief after major surgery // Br J Anaesth. 2002; 88(2): 227-233.
  14. Fuzier R., Belbachir A., Gall O., Keita H. Postoperative analgesia in 'particular situations’. Practical recommendations // Ann. Fr. Anesth. Reanim. 2008; 27(4): 966-968.
  15. Gray A. M., Nevinson M. J., Sewell R. D. E. The involvement of opioidergic and noradrenergic mechanisms in nefopam antinociception // Eur. J. Pharmacol. 1999; 365(2-3): 149-157.
  16. Guirimand F., Dupont X., Bouhassira D., Brasseur L., Chauvin M. Nefopam strongly depresses the nociceptive flexion RIII reflex in humans // Pain. 1999; 80(1-2): 399-404.
  17. Hagemann K., Platte G., Meyer J., Effert S. Haemodynamic effects of nefopam (author's transl) // Dtsch. Med. Wochenschr. 1978; 103(25): 1040-1043.
  18. Heel R. C., Brogden R. N., Pakes G. E., Speight T. M., Avery G. S. Nefopam: a review of its pharmacological properties and therapeutic efficacy // Drugs. 1980; 9(4): 249-267.
  19. Kakkar M., Derry S., Moore R. A., McQuay H. J. Single dose oral nefopam for acute postoperative pain in adults // Cochrane Database Syst. Rev. 2009 8;(3): CD007442.
  20. Kehlet H., Dahl J. B. The value of “multimodal” or “balanced analgesia” in postoperative pain treatment // Anesth. Analg. 1993; 77(5): 1048-1056.
  21. Lai K. C., Lam S. K., Chu K. M, Wong B. C., Hui W. М., Hu W. H. [et al.] Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use // N. Engl. J. Med. 2002; 346(26): 2033-2038.
  22. McLintock T. T., Kenny G. N., Howie J. C., McArdle C. S., Lawrie S., Aitken H. Assessment of the analgesic efficacy of nefopam hydrochloride after upper abdominal surgery: a study using patient controlled analgesia // Br. J. Surg. 1988; 75(8): 779-781.
  23. Mimoz O., Incagnoli P., Josse C., Gillon M. C., Kuhlman L., Mirand A. [et al.] Analgesic efficacy and safety of nefopam vs. propacetamol following hepatic resection // Anaesthesia. 2001; 56(6): 520-525.
  24. Moiniche S., Romsing J., Dahl J. B., Tramer M. R. Nonsteroidal antiinflammatory drugs and the risk of operative site bleeding after tonsillectomy: a quantitative systematic review // Anesth. Analg. 2003; 96(1): 68-77.
  25. Pillans P. I., Woods D. J. Adverse reactions associated with nefopam // N. Z. Med. J. 1995; 108(1008): 382-324.
  26. Ochroch J., Mardini I. A., Gottschalk A. What is the role of NSAIDs in pre-emptive analgesia? // Drags. 2003; 63(24): 2709-2723.
  27. Tirault M., Derrode N., Clevenot D., Rolland D., Fletcher D., Debaene B. The effect of nefopam on morphine overconsumption induced by large-dose remifentanil during propofol anesthesia for major abdominal surgery // Anesth. Analg. 2006; 102(1): 110-117.
  28. Urwin S. C., Smith H. S. Fatal nefopam overdose // Br. J. Anaesth. 1999: 83(3): 501-502.
  29. Verleye M., Andre N., Heulard I., Gillardin J. M. Nefopam blocks voltage-sensitive sodium channels and modulates glutamatergic transmission in rodents // Brain. Res. 2004; 1013(2): 249-255.
  30. Zhang J., Ding E. L., Song Y. Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials // JAMA. 2006; 296(13): 1619-1632.

Copyright (c) 2013 Eco-Vector


 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies