Chronic post-thoracotomic pain syndrome in cardiothoracic surgery after minimally invasive coronary bypass surgery: prospective cohort study

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

BACKGROUND: No consensus has been established on the role of epidural anesthesia in relation to the prevention of chronic post-thoracotomic pain during minimally invasive coronary bypass surgery.

OBJECTIVE: This study aimed to evaluate the effect of epidural anesthesia on the incidence of chronic post-thoracotomic pain syndrome after minimally invasive direct coronary artery bypass (MIDCAB) surgery.

MATERIALS AND METHODS: The study included 87 patients who underwent MIDCAB surgery. In group 1, epidural anesthesia was performed before the induction of general anesthesia; in group 2, the operation was performed only under general anesthesia.

RESULTS: The use of fentanyl for anesthesia varied: 0.5 (0.5; 0.6) mg in group 1 versus 3.5 (3.3; 3.6) mg in group 2 (p <0.01). The incidence of chronic post-thoracotomic pain in patients 3 months after surgery was higher in group 2 than in group 1 (39.1% vs 17.2%, p=0.005). The severity of pain at rest was 3 points (2; 3) in group 1 and 3 points (3; 3.5) in group 2 (p=0.018); however, during a deep breath, these differences became insignificant: 4 points (4; 4) in group 1 and 4 (4; 5) points in group 2 (p=0.453). At 6 months after surgery, chronic post-thoracotomic pain was present in 15.6% of the patients in group 1 and 34.8% in group 2 (p=0.011). After 6 months, the severity of pain at rest was 2.5 (2; 3) in group 1 and 3 (3; 3.75) in group 2 (p=0.01). No differences in cough were found: 4 (3.75; 4) points in group 1 and 4 (4; 4.5) points in group 2 (p >0.05).

CONCLUSION: The use of epidural anesthesia led to a decrease in the incidence of chronic post-thoracotomic pain in patients undergoing MIDCAB surgery.

About the authors

Anatoliy V. Stukalov

Kirov Military Medical Academy

Author for correspondence.
Email: zamkom-vma@mail.ru
ORCID iD: 0000-0002-3869-9043
SPIN-code: 9636-6856

researcher

Russian Federation, St. Petersburg

Roman E. Lakhin

Kirov Military Medical Academy

Email: zamkom-vma@mail.ru
ORCID iD: 0000-0001-6819-9691
SPIN-code: 7261-9985

MD, Dr. Sci. (Med.), associate professor

Russian Federation, St. Petersburg

Alexander N. Gritsai

Kirov Military Medical Academy

Email: zamkom-vma@mail.ru
ORCID iD: 0000-0001-5909-7810
SPIN-code: 6756-7894

MD, Cand. Sci. (Med.)

Russian Federation, St. Petersburg

Eugene N. Ershov

Kirov Military Medical Academy

Email: zamkom-vma@mail.ru
ORCID iD: 0000-0002-9572-6802
SPIN-code: 1837-5183

MD, Cand. Sci. (Med.)

Russian Federation, St. Petersburg

Nikolay V. Stukalov

Kirov Military Medical Academy

Email: zamkom-vma@mail.ru
ORCID iD: 0000-0001-7928-2132
SPIN-code: 9213-4640

clinical resident

Russian Federation, St. Petersburg

Evgenii Yu. Garbuzov

City hospital No. 40

Email: zamkom-vma@mail.ru
ORCID iD: 0000-0003-2990-0320

department head, anesthesiologist-resuscitator

Russian Federation, St. Petersburg

References

  1. Khubulava GG, Kravchuk VN, Kniazev EA, et al. Direct revascularization of the myocardum from left-sided mini-thoracotomy — modern performance of the operation named after V.I. Kolesov. Vestn Khir Im II Grek. 2015;174(2):20–24. (In Russ). doi: 10.24884/0042-4625-2015-174-2-20-24
  2. Kolessov VI. Mammary artery-coronary artery anastomosis as method of treatment for angina pectoris. The Journal of Thoracic and Cardiovascular Surgery. 1967;54(4): 535–544. doi: 10.1016/S0022-5223(19)43061-4
  3. Benetti FJ, Ballester C. Use of thoracoscopy and a minimal thoracotomy, in mammary-coronary bypass to left anterior descending artery, without extracorporeal circulation. Experience in 2 cases. J Cardiovasc Surg (Torino). 1995;36(2):159–161.
  4. Calafiore AM, Giammarco G, Teodori G, et al. Left anterior descending coronary artery grafting via left anterior small thoracotomy without cardiopulmonary bypass. Ann Thorac Surg. 1996;61(6):1658–1665. doi: 10.1016/0003-4975(96)00187-7
  5. Xu Y, Li Y, Bao W, Qiu S. MIDCAB versus off-pump CABG: Comparative study. Hellenic J Cardiol. 2020;61(2):120–124. doi: 10.1016/j.hjc.2018.12.004
  6. Schaff HV. New surgical techniques: implications for the cardiac anesthesiologist: mini-thoracotomy for coronary revascularization without cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 1997;11(2_Suppl 1):6–9;discussion 24–25. doi: 10.1016/s1053-0770(97)80003-1
  7. Hamilton C, Alfille P, Mountjoy J, Bao X. Regional anesthesia and acute perioperative pain management in thoracic surgery: a narrative review. J Thorac Dis. 2022;14(6):2276–2296. doi: 10.21037/jtd-21-1740
  8. Peng Z, Li H, Zhang C, et al. A retrospective study of chronic post-surgical pain following thoracic surgery: prevalence, risk factors, incidence of neuropathic component, and impact on qualify of life. PLoS One. 2014;9(2):e90014. doi: 10.1371/journal.pone.0090014
  9. Maloney J, Wie C, Pew S, et al. Post-thoracotomy Pain Syndrome. Curr Pain Headache Rep. 2022;26(9):677–681. doi: 10.1007/s11916-022-01069-z
  10. Dango S, Harris S, Offner K, et al. Combined paravertebral and intrathecal vs thoracic epidural analgesia for post-thoracotomy pain relief. Br J Anaesth. 2013;110(3):443–449. doi: 10.1093/bja/aes394
  11. Ding W, Chen Y, Li D, et al. Investigation of single-dose thoracic paravertebral analgesia for postoperative pain control after thoracoscopic lobectomy — A randomized controlled trial. Int J Surg. 2018;57:8–14. doi: 10.1016/j.ijsu.2018.07.006
  12. Volchkov VA, Boyarkin AA, Balandina EV, et al. Influence of inhalation and epidural anesthesia on the development of complications after coronary artery bypass grafting. Thoracic and Cardiovascular Surgery. 2019;61(6):525–531. (In Russ). doi: 10.24022/0236-2791-2019-61-6-525-531
  13. Koryachkin VA, Zabolotskiy DV. The place of regional methods of anesthesia in surgical anesthesia. Medicine: Theory and Practice. 2018;3(4): 65–69. (In Russ).
  14. Ovechkin AM, Bayalieva AZh, Ezhevskaya AA, et al. Postoperative analgesia. Guidelines. Annals of Critical Care. 2019;4:9–33. (In Russ). doi: 10.21320/1818-474X-2019-4-9-33
  15. Exadaktylos AK, Trampitsch E, Mares P, et al. Pre-operative intercostal nerve blockade for minimally invasive coronary bypass surgery: a standardised anaesthetic regimen for rapid emergence and early extubation. Cardiovasc J S Afr. 2004;15(4):178–181.
  16. Porrello C, Scerrino G, Vaglica A, et al. Postoperative complications, pain and quality of life after thoracoscopic or thoracotomic lobectomy for lung cancer. G Chir. 2019;40(2):115–119.
  17. Koryachkin VA, Spasova AP, Khinovker VV. Neuropathic pain. Innovative Medicine of Kuban. 2021;(2):58–64. (In Russ). doi: 10.35401/2500-0268-2021-22-2-58-64
  18. Khoronenko VE, Malanova AS, Baskakov DS, et al. The use of regional and peripheral blockades for the prevention of chronic post-thoracotomy pain syndrome in oncosurgical practice. Pirogov Russian Journal of Surgery = Khirurgiya. Zurnal im. N.I. Pirogova. 2017;8:58–63. (In Russ). doi: 10.17116/hirurgia2017858-63
  19. Gautam S, Pande S, Agarwal A, et al. Evaluation of Serratus Anterior Plane Block for Pain Relief in Patients Undergoing MIDCAB Surgery. Innovations (Phila). 2020;15(2):148–154. doi: 10.1177/1556984520908962

Supplementary files

Supplementary Files
Action
1. JATS XML
2. Fig. 1. Study scheme.

Download (260KB)

Copyright (c) 2022 Stukalov A.V., Lakhin R.E., Gritsai A.N., Ershov E.N., Stukalov N.V., Garbuzov E.Y.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies