Chronic post-thoracotomic pain syndrome in cardiothoracic surgery after minimally invasive coronary bypass surgery: prospective cohort study
- Authors: Stukalov A.V.1, Lakhin R.E.1, Gritsai A.N.1, Ershov E.N.1, Stukalov N.V.1, Garbuzov E.Y.2
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Affiliations:
- Kirov Military Medical Academy
- City hospital No. 40
- Issue: Vol 16, No 4 (2022)
- Pages: 279-288
- Section: Original articles
- URL: https://journals.rcsi.science/1993-6508/article/view/131773
- DOI: https://doi.org/10.17816/RA112304
- ID: 131773
Cite item
Abstract
BACKGROUND: No consensus has been established on the role of epidural anesthesia in relation to the prevention of chronic post-thoracotomic pain during minimally invasive coronary bypass surgery.
OBJECTIVE: This study aimed to evaluate the effect of epidural anesthesia on the incidence of chronic post-thoracotomic pain syndrome after minimally invasive direct coronary artery bypass (MIDCAB) surgery.
MATERIALS AND METHODS: The study included 87 patients who underwent MIDCAB surgery. In group 1, epidural anesthesia was performed before the induction of general anesthesia; in group 2, the operation was performed only under general anesthesia.
RESULTS: The use of fentanyl for anesthesia varied: 0.5 (0.5; 0.6) mg in group 1 versus 3.5 (3.3; 3.6) mg in group 2 (p <0.01). The incidence of chronic post-thoracotomic pain in patients 3 months after surgery was higher in group 2 than in group 1 (39.1% vs 17.2%, p=0.005). The severity of pain at rest was 3 points (2; 3) in group 1 and 3 points (3; 3.5) in group 2 (p=0.018); however, during a deep breath, these differences became insignificant: 4 points (4; 4) in group 1 and 4 (4; 5) points in group 2 (p=0.453). At 6 months after surgery, chronic post-thoracotomic pain was present in 15.6% of the patients in group 1 and 34.8% in group 2 (p=0.011). After 6 months, the severity of pain at rest was 2.5 (2; 3) in group 1 and 3 (3; 3.75) in group 2 (p=0.01). No differences in cough were found: 4 (3.75; 4) points in group 1 and 4 (4; 4.5) points in group 2 (p >0.05).
CONCLUSION: The use of epidural anesthesia led to a decrease in the incidence of chronic post-thoracotomic pain in patients undergoing MIDCAB surgery.
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##article.viewOnOriginalSite##About the authors
Anatoliy V. Stukalov
Kirov Military Medical Academy
Author for correspondence.
Email: zamkom-vma@mail.ru
ORCID iD: 0000-0002-3869-9043
SPIN-code: 9636-6856
researcher
Russian Federation, St. PetersburgRoman E. Lakhin
Kirov Military Medical Academy
Email: zamkom-vma@mail.ru
ORCID iD: 0000-0001-6819-9691
SPIN-code: 7261-9985
MD, Dr. Sci. (Med.), associate professor
Russian Federation, St. PetersburgAlexander N. Gritsai
Kirov Military Medical Academy
Email: zamkom-vma@mail.ru
ORCID iD: 0000-0001-5909-7810
SPIN-code: 6756-7894
MD, Cand. Sci. (Med.)
Russian Federation, St. PetersburgEugene N. Ershov
Kirov Military Medical Academy
Email: zamkom-vma@mail.ru
ORCID iD: 0000-0002-9572-6802
SPIN-code: 1837-5183
MD, Cand. Sci. (Med.)
Russian Federation, St. PetersburgNikolay V. Stukalov
Kirov Military Medical Academy
Email: zamkom-vma@mail.ru
ORCID iD: 0000-0001-7928-2132
SPIN-code: 9213-4640
clinical resident
Russian Federation, St. PetersburgEvgenii Yu. Garbuzov
City hospital No. 40
Email: zamkom-vma@mail.ru
ORCID iD: 0000-0003-2990-0320
department head, anesthesiologist-resuscitator
Russian Federation, St. PetersburgReferences
- Khubulava GG, Kravchuk VN, Kniazev EA, et al. Direct revascularization of the myocardum from left-sided mini-thoracotomy — modern performance of the operation named after V.I. Kolesov. Vestn Khir Im II Grek. 2015;174(2):20–24. (In Russ). doi: 10.24884/0042-4625-2015-174-2-20-24
- Kolessov VI. Mammary artery-coronary artery anastomosis as method of treatment for angina pectoris. The Journal of Thoracic and Cardiovascular Surgery. 1967;54(4): 535–544. doi: 10.1016/S0022-5223(19)43061-4
- Benetti FJ, Ballester C. Use of thoracoscopy and a minimal thoracotomy, in mammary-coronary bypass to left anterior descending artery, without extracorporeal circulation. Experience in 2 cases. J Cardiovasc Surg (Torino). 1995;36(2):159–161.
- Calafiore AM, Giammarco G, Teodori G, et al. Left anterior descending coronary artery grafting via left anterior small thoracotomy without cardiopulmonary bypass. Ann Thorac Surg. 1996;61(6):1658–1665. doi: 10.1016/0003-4975(96)00187-7
- Xu Y, Li Y, Bao W, Qiu S. MIDCAB versus off-pump CABG: Comparative study. Hellenic J Cardiol. 2020;61(2):120–124. doi: 10.1016/j.hjc.2018.12.004
- Schaff HV. New surgical techniques: implications for the cardiac anesthesiologist: mini-thoracotomy for coronary revascularization without cardiopulmonary bypass. J Cardiothorac Vasc Anesth. 1997;11(2_Suppl 1):6–9;discussion 24–25. doi: 10.1016/s1053-0770(97)80003-1
- Hamilton C, Alfille P, Mountjoy J, Bao X. Regional anesthesia and acute perioperative pain management in thoracic surgery: a narrative review. J Thorac Dis. 2022;14(6):2276–2296. doi: 10.21037/jtd-21-1740
- Peng Z, Li H, Zhang C, et al. A retrospective study of chronic post-surgical pain following thoracic surgery: prevalence, risk factors, incidence of neuropathic component, and impact on qualify of life. PLoS One. 2014;9(2):e90014. doi: 10.1371/journal.pone.0090014
- Maloney J, Wie C, Pew S, et al. Post-thoracotomy Pain Syndrome. Curr Pain Headache Rep. 2022;26(9):677–681. doi: 10.1007/s11916-022-01069-z
- Dango S, Harris S, Offner K, et al. Combined paravertebral and intrathecal vs thoracic epidural analgesia for post-thoracotomy pain relief. Br J Anaesth. 2013;110(3):443–449. doi: 10.1093/bja/aes394
- Ding W, Chen Y, Li D, et al. Investigation of single-dose thoracic paravertebral analgesia for postoperative pain control after thoracoscopic lobectomy — A randomized controlled trial. Int J Surg. 2018;57:8–14. doi: 10.1016/j.ijsu.2018.07.006
- Volchkov VA, Boyarkin AA, Balandina EV, et al. Influence of inhalation and epidural anesthesia on the development of complications after coronary artery bypass grafting. Thoracic and Cardiovascular Surgery. 2019;61(6):525–531. (In Russ). doi: 10.24022/0236-2791-2019-61-6-525-531
- Koryachkin VA, Zabolotskiy DV. The place of regional methods of anesthesia in surgical anesthesia. Medicine: Theory and Practice. 2018;3(4): 65–69. (In Russ).
- Ovechkin AM, Bayalieva AZh, Ezhevskaya AA, et al. Postoperative analgesia. Guidelines. Annals of Critical Care. 2019;4:9–33. (In Russ). doi: 10.21320/1818-474X-2019-4-9-33
- Exadaktylos AK, Trampitsch E, Mares P, et al. Pre-operative intercostal nerve blockade for minimally invasive coronary bypass surgery: a standardised anaesthetic regimen for rapid emergence and early extubation. Cardiovasc J S Afr. 2004;15(4):178–181.
- Porrello C, Scerrino G, Vaglica A, et al. Postoperative complications, pain and quality of life after thoracoscopic or thoracotomic lobectomy for lung cancer. G Chir. 2019;40(2):115–119.
- Koryachkin VA, Spasova AP, Khinovker VV. Neuropathic pain. Innovative Medicine of Kuban. 2021;(2):58–64. (In Russ). doi: 10.35401/2500-0268-2021-22-2-58-64
- Khoronenko VE, Malanova AS, Baskakov DS, et al. The use of regional and peripheral blockades for the prevention of chronic post-thoracotomy pain syndrome in oncosurgical practice. Pirogov Russian Journal of Surgery = Khirurgiya. Zurnal im. N.I. Pirogova. 2017;8:58–63. (In Russ). doi: 10.17116/hirurgia2017858-63
- Gautam S, Pande S, Agarwal A, et al. Evaluation of Serratus Anterior Plane Block for Pain Relief in Patients Undergoing MIDCAB Surgery. Innovations (Phila). 2020;15(2):148–154. doi: 10.1177/1556984520908962