THE EXPERIMENTAL RABBIT «DRY EYE» MODELS


Cite item

Full Text

Abstract

Various experimental rabbit «dry eye» models available for the investigations into different forms and pathogenetic mechanisms of the «dry eye» condition are described with special reference to their advantages and drawbacks. Their understanding is believed to be helpful for the choice of an adequate model for the solution of concrete clinical problems and the development of new methods for the management of the disease being considered. The authors emphasized that the search for new therapeutic methods and the evaluation of the existing ones are impossible without the use of «dry eye» models.

About the authors

Kseniya Evgen’evna Seliverstova

Moscow Helmholtz Research Institute of Eye Diseases Ministry of Health of the Russian Federation

Email: xenia2002@list.ru
105062, Moscow, Russian Federation

Elena Sergeevna Vakhova

Moscow Helmholtz Research Institute of Eye Diseases Ministry of Health of the Russian Federation

105062, Moscow, Russian Federation

Elena Vladimirovna Yani

Moscow Helmholtz Research Institute of Eye Diseases Ministry of Health of the Russian Federation

105062, Moscow, Russian Federation

Victoria Viktorovna Pozdnyakova

Moscow Helmholtz Research Institute of Eye Diseases Ministry of Health of the Russian Federation

105062, Moscow, Russian Federation

Diana Ibragimovna Ibragimova

Moscow Helmholtz Research Institute of Eye Diseases Ministry of Health of the Russian Federation

105062, Moscow, Russian Federation

References

  1. Schaumberg D.A., Sullivan D.A., Buring J.A, Dana M.R. Prevalence of dry eye syndrome among US women. Am. J. Ophthalmol. 2003; 136: 318—26.
  2. Майчук Д.Ю. Клинико-экспериментальное доказательство роли воспаления в патогенезе вторичного «сухого глаза». В кн.: Современные методы диагностики и лечения заболеваний слезных органов. В кн.: Материалы научно-практической конференции: Сборник научных статей. М.; 2005; 209—15.
  3. Labbe A., Pauly A., Liang H., Brignole-Baudouin F., Martin C. et al. Comparison of toxicological profiles of benzalconium chloride and polyquaternium-1: an experimental study. J. Ocul. Pharmacol. Ther. 2006; 22: 267—78.
  4. Lin Z., Liu X., Zhou Т. et al. A mouse dry eye model induced by topical administration of benzalconium chloride. Mol. Vis. 2011; 25: 257—64.
  5. Strong B., Farley W., Stern M.E. et al. Topical cyclosporine inhibits conjunctival epithelial apoptosis in experimental murine keratoconjunctivitis sicca. Cornea. 2005; 24: 80—5.
  6. Бржеский В.В., Сомов Е.Е. Роговично-конъюнктивальный ксероз (диагностика, клиника, лечение). 2-е изд. СПб.; 2003.
  7. Barabino S., Dana M.R. Animal models of dry eye: a critical assessment of opportunities and limitations. Invest. Ophthalmol. Vis. Sci. 2004; 45: 1641—6.
  8. Guo Z., Song D., Azzarolo A.M., Schechter J.E., Warren D.W., Wood R.L. et al. Autologous lacrimal-lymphoid mixed-cell reactions induce dacryoadenitis in rabbits. Exp. Eye Res. 2000; 71: 23—31.
  9. Zhu Z., Stevenson D., Schechter J.E., Mircheff A.K., Atkinson R., Trousdale M.D. Lacrimal histopathology and ocular surface disease in a rabbit model of autoimmune dacryoadenitis. Cornea. 2003; 22: 25—32.
  10. Kumar P.A., Macleod A.M., O’Brien B.M., Hickey M.J., Knight K.R. Microvascular submandibular gland transfer for the management of xerophthalmia; an experimental study. Br. J. Plast. Surg. 1990; 43: 431—6.
  11. Gilbard J.P., Rossi S.R., Gray K.L. A new rabbit model for keratoconjunctivitis sicca. Invest. Ophthalmol. Vis. Sci. 1987; 28: 225—8.
  12. Hakim S.G., Schroder C., Geerling G., Lauer I., Wedel T. et al. Early and late immunohistochemical and ultrastructural changes associated with functional impairment of the lachrymal gland following external beam radiation. Int. J. Exp. Pathol. 2006; 87: 65—71.
  13. Burgalassi S., Panichi L., Chetoni P., Saettone M.F., Boldrini E. Development of a simple dry eye model in the albino rabbit and evaluation of some tear substitutes. Ophthalm. Res. 1999; 31: 229—35.
  14. Позднякова В.В, Яни Е.В., Ибрагимова Д.И. Экспериментальные исследования влияния раствора атропина сульфата 1% на слезопродукцию у кроликов. Российский офтальмологический журнал. 2012; 4: 80—2.
  15. Demetriades A.M., Leyngold I.M., D’Anna S., Eghrari A.O., Emmert D.G., Grant M.P., Merbs S.L. Intraglandular injection of botulinum toxin a reduces tear production in rabbits. Ophthalm. Plast. Reconstr. Surg. 2013; 29: 21—4.
  16. Обрубов С.А., Ставицкая Г.В., Обрубова Г.А., Обрубов А.С. Морфологические особенности мейбомиевых желез в экспериментальной модели хирургической менопаузы крольчих. В кн.: VIII Всероссийская научно-практическая конференция с международным участием: Сборник научных статей. М.; 2009; 566.
  17. Sullivan D.A., Sullivan D.B., Evans J.E. et. al. Androgen deficiency, meibomian gland dysfunction, and evaporative dry eye. Ann. N.Y. Acad. Sci. 2002; 966: 211—22.
  18. Rolando M., Refojo M.F. Tear evaporimeter for measuring water evaporation rate from the tear film under controlled conditions in humans. Exp. Eye Res. 1983; 36: 25—33.
  19. Иванов А.Н. Воздействие препарата Селекартен на модель «сухого глаза» у кролика. В кн.: Современные методы диагностики и лечения заболеваний роговицы и склеры. В кн.: Материалы научно-практической конференции: Сборник научных статей. М.; 2007; 1: 243—5.
  20. Fujihara T., Nagano T., Nakamura M. et al. Establishment of a rabbit short-term dry eye model. J. Ocul. Pharmacol. 1995; 11: 503—8.
  21. Nakamura S., Okada S., Umeda Y., Saito F. Development of a rabbit model of tear film instability and evaluation of viscosity of artificial tear preparations. Cornea. 2004; 23: 390—7.
  22. Chen Z.Y., Liang Q.F., Yu G.Y. Establishment of a rabbit model for keratoconjunctivitis sicca. Cornea. 2011; 30: 1024—9.
  23. Wensheng C., Zhiyuan Li., Jiaoyue Hu. et al. Corneal alternations induced by topical application of benzalkonium chloride in rabbit. PLoS One. 2011; 6: e26103.
  24. Pisella P.J., Fillacier K., Elena P.P. et al. Comparison of the effects of preserved and unpreserved formulations of timolol on the ocular surface of albino rabbits. Ophthalm. Res. 2000; 32: 3—8.
  25. Swan K.C. Reactivity of the ocular tissue to wetting agents. Am. J. Ophthalmol. 1944; 27: 1118—22.

Copyright (c) 2013 Eco-Vector


 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies