Clinical features of internal fistula obliteration after trabeculectomy in congenital glaucoma and the possibility of laser treatment

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Abstract

AIM: This study aimed to evaluate the clinical features of internal fistula obliteration after trabeculectomy (TE) in children with congenital glaucoma and the possibility of laser treatment.

MATERIAL AND METHODS: The study included 73 eyes of 56 children with congenital glaucoma who underwent TE between 3 months and 16 years. Yttrium aluminum garnet (YAG) laser refistulization was performed postoperatively because gonioscopy results revealed a complete or partial block of the internal fistula. In addition, a patented technique was utilized that combines the use of defocused and focused YAG laser radiation.

RESULTS: The internal fistula was more often blocked by the iris root. YAG laser refistulization eliminated the block in 97.3% of cases, and in two cases, planar splices that had existed for >6 months could not be dissected. Laser removal of the internal fistula block in 97.3% of cases led to a normalization of the intraocular pressure (IOP) immediately after surgery and in 80.7% of cases in the subsequent year. Early refistulization (up to 3 months after TE) reduced the risk of IOP decompensation by 2.6 times by the annual follow-up.

CONCLUSION: In children with congenital glaucoma, internal fistula obliteration (both complete and partial) by the iris root, iridotrabecular or iridocorneal contact, fusion, or pigment may occur at the earliest stages after TE, which is an indication of laser refistulization. When the internal fistula is overgrown after TE in children with congenital glaucoma, YAG laser refistulization allows restoring the lumen of the internal fistula in 97.3% of cases. Therefore, for timely detection and elimination of the blockade, gonioscopic monitoring of the internal fistula is necessary both at the earliest possible time and in the long term after TE.

About the authors

Nataliya N. Arestova

Helmholtz National Medical Research Center of Eye Diseases; A.I. Evdokimov Moscow State University of Medicine and Dentistry

Author for correspondence.
Email: arestovann@gmail.com
ORCID iD: 0000-0002-8938-2943
SPIN-code: 4875-6288

MD, Dr. Sci. (Med.)

Russian Federation, Moscow; Moscow

Anna Yu. Panova

Helmholtz National Medical Research Center of Eye Diseases

Email: annie_panova18@mail.ru
ORCID iD: 0000-0003-2103-1570
SPIN-code: 9930-4813

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

Sofia A. Kireeva

Helmholtz National Medical Research Center of Eye Diseases

Email: 19sofia199611@gmail.com
ORCID iD: 0009-0000-4623-9664

MD, doctor

Russian Federation, Moscow

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Supplementary files

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2. Fig. 1. Partial block of the internal fistula.

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3. Fig. 2. Complete block of the internal fistula.

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4. Fig. 3. Iridotrabecular contact or fusion in the lumen area of the internal fistula.

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5. Fig. 4. Layer of pigment overlays covering the lumen of the internal fistula.

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6. Fig. 5. Films in the profile of the internal fistula.

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7. Fig. 6. Ingrowing of the edges of the postoperative iris coloboma into the area of the internal fistula.

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8. Fig. 7. Iridotrabecular fusion in the internal fistula zone (a complete block with the growth of the postoperative iris coloboma): a — before laser surgery; b — аfter laser surgery, the internal fistula and iris coloboma are free of splices.

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Copyright (c) 2023 Arestova N.N., Panova A.Y., Kireeva S.A.

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