Immediate results of micropulse cyclophotocoagulation in glaucoma in children

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Abstract

AIM: This study aimed to investigate the efficacy and safety of micropulse cyclophotocoagulation (MP-CPC) in the treatment of various types of glaucoma in children.

MATERIAL AND METHODS: The study included 14 children (15 eyes) with uncompensated glaucoma of various etiologies, who underwent MP-CPC using the Cyclo G6 laser system (IRIDEX, USA). The intervention was considered absolutely effective when IOP reached 8 to 25 mm Hg without medications and without signs of progression of glaucoma, relatively effective, when the same criteria are achieved with hypotensive medications.

RESULTS: The average age of children at the time of intervention was 8.5±1.5 yr (from 7 months to 17 yr). The average level of IOP before surgery was 28.5±1.1 mm Hg, 3 days after MP-CPC (18.87±1.04 mm Hg), while the absolute efficiency was 14.3%, relative — 100%. By the end of the observation period (1–6 months; on average, 2.5±0.4 months), the average IOP was 24.4±1.31 mm Hg (average decrease, 14.3%), with absolute efficiency of 0% and relative of 66.7%. The average number of hypotensive medications received in instillations did not change significantly before and after MP-CPC and amounted to 3.45±0.22 and 2.91±0.39, respectively (p=0.167). Complications after MP-CPC were detected in six eyes (40%); in all cases, the appearance or increase of the inflammatory reaction in the anterior chamber was observed. In addition, in two eyes (13.3%). In addition, a slight mydriasis (4–5 mm) developed.

CONCLUSION: MP-CPC is a safe and effective treatment for glaucoma in children with various etiologies. Further research is needed to evaluate the effectiveness of intervention in the long term and the safety of repeated procedures to achieve normal IOP and to develop individual schemes of MP-CPC.

About the authors

Anna Yu. Panova

Helmholtz National Medical Research Center of Eye Diseases

Email: annie_panova18@mail.ru
ORCID iD: 0000-0003-2103-1570
SPIN-code: 9930-4813

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

Lyudmila A. Katargina

Helmholtz National Medical Research Center of Eye Diseases

Email: katargina@igb.ru
ORCID iD: 0000-0002-4857-0374

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Ekaterina V. Denisova

Helmholtz National Medical Research Center of Eye Diseases

Author for correspondence.
Email: deale_2006@inbox.ru
ORCID iD: 0000-0003-3735-6249
SPIN-code: 4111-4330

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

Aleхаndеr A. Sorokin

Helmholtz National Medical Research Center of Eye Diseases

Email: a.a.sorokin@inbox.ru
ORCID iD: 0000-0002-8213-8518

Graduate Student

Russian Federation, Moscow

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Copyright (c) 2022 Panova A.Y., Katargina L.A., Denisova E.V., Sorokin A.A.

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