Effect of solvent type and concentration on size and morphology of arbidol microparticles obtained by supercritical antisolvent precipitation


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The capability of arbidol microparticle preparation by supercritical antisolvent (SAS) precipitation was demonstrated. A nonmonotonic dependence of the average particle size on the concentration was found, while the position of the minimum is dependent on the type of solvent used. It is possible to prepare Arbidol particles of various morphology and size from several microns to several hundred microns depending on the conditions.

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A. Vorobei

Kurnakov Institute of General and Inorganic Chemistry; Department of Chemistry

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Email: vorobei@supercritical.ru
俄罗斯联邦, Moscow; Moscow

O. Pokrovskiy

Kurnakov Institute of General and Inorganic Chemistry

Email: vorobei@supercritical.ru
俄罗斯联邦, Moscow

K. Ustinovich

Kurnakov Institute of General and Inorganic Chemistry

Email: vorobei@supercritical.ru
俄罗斯联邦, Moscow

L. Krotova

Institute of Laser and Information Technologies

Email: vorobei@supercritical.ru
俄罗斯联邦, Moscow

O. Parenago

Kurnakov Institute of General and Inorganic Chemistry; Department of Chemistry

Email: vorobei@supercritical.ru
俄罗斯联邦, Moscow; Moscow

V. Lunin

Kurnakov Institute of General and Inorganic Chemistry; Department of Chemistry

Email: vorobei@supercritical.ru
俄罗斯联邦, Moscow; Moscow

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