Mechanisms of perioperative corneal abrasions: Alterations in the tear film proteome

E. Yu. Zernii; O. S. Gancharova; I. E. Ishutina; V. E. Baksheeva; M. O. Golovastova; E. I. Kabanova; M. S. Savchenko; M. V. Serebryakova; L. F. Sotnikova; A. A. Zamyatnin; P. P. Philippov; I. I. Senin

doi:10.1134/S1990750817020123

Mechanisms of perioperative corneal abrasions: Alterations in the tear film proteome

Авторлар: Zernii E.Y.¹, Gancharova O.S.¹, Ishutina I.E.², Baksheeva V.E.¹, Golovastova M.O.¹, Kabanova E.I.², Savchenko M.S.¹, Serebryakova M.V.¹, Sotnikova L.F.², Zamyatnin A.A.¹^,3, Philippov P.P.¹, Senin I.I.¹
Мекемелер:
1. Belozersky Institute of Physico-Chemical Biology
2. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
3. Institute of Molecular Medicine
Шығарылым: Том 11, № 2 (2017)
Беттер: 186-193
Бөлім: Article
URL: https://journals.rcsi.science/1990-7508/article/view/197799
DOI: https://doi.org/10.1134/S1990750817020123
ID: 197799

Дәйексөз келтіру

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Аннотация

Perioperative corneal abrasion is a common ophthalmic complication detectable in patients undergoing general anesthesia. In this study, using experimental perioperative corneal abrasion in animals (rabbits) correlations have been found between development of corneal abrasion and proteomic changes in the tear film. The process of accumulation of pathological changes in the cornea begins after 1 h of general anesthesia while after 3–6 h of general anesthesia clinically manifested abrasions have been recognized. The development of corneal abrasions was associated with different changes in the content of the major proteins of the tear film. Analysis of the tear proteome points to suppressed lachrymal gland functioning, and suggests that serotransferrin, serum albumin and annexin A1 may be applicable as potential tear markers of the ophthalmic complication. The biochemical changes in the tear film included the rapid decrease in total antioxidant activity and activity of superoxide dismutase, as well as the decrease in interleukin-4 and the increase in interleukin-6 content thus indicating development of oxidative and pro-inflammatory responses. These findings suggest that antioxidant and anti-inflammatory therapy is a prospective approach for prevention/treatment of perioperative corneal abrasions. The observed anesthesia-induced effects should be taken into consideration in any study of ocular surface diseases employing anesthetized animals.

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general anesthesia, corneal abrasion, dry eye, tear proteome, antioxidant activity, pro-inflammatory response

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Mechanisms of perioperative corneal abrasions: Alterations in the tear film proteome

Толық мәтін

Аннотация

Негізгі сөздер

Авторлар туралы

E. Zernii

O. Gancharova

I. Ishutina

V. Baksheeva

M. Golovastova

E. Kabanova

M. Savchenko

M. Serebryakova

L. Sotnikova

A. Zamyatnin

P. Philippov

I. Senin

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