电邮这篇文章 Mechanisms of perioperative corneal abrasions: Alterations in the tear film proteome
- 作者: Zernii E.Y.1, Gancharova O.S.1, Ishutina I.E.2, Baksheeva V.E.1, Golovastova M.O.1, Kabanova E.I.2, Savchenko M.S.1, Serebryakova M.V.1, Sotnikova L.F.2, Zamyatnin A.A.1,3, Philippov P.P.1, Senin I.I.1
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隶属关系:
- Belozersky Institute of Physico-Chemical Biology
- Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
- Institute of Molecular Medicine
- 期: 卷 11, 编号 2 (2017)
- 页面: 186-193
- 栏目: Article
- URL: https://journals.rcsi.science/1990-7508/article/view/197799
- DOI: https://doi.org/10.1134/S1990750817020123
- ID: 197799
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详细
Perioperative corneal abrasion is a common ophthalmic complication detectable in patients undergoing general anesthesia. In this study, using experimental perioperative corneal abrasion in animals (rabbits) correlations have been found between development of corneal abrasion and proteomic changes in the tear film. The process of accumulation of pathological changes in the cornea begins after 1 h of general anesthesia while after 3–6 h of general anesthesia clinically manifested abrasions have been recognized. The development of corneal abrasions was associated with different changes in the content of the major proteins of the tear film. Analysis of the tear proteome points to suppressed lachrymal gland functioning, and suggests that serotransferrin, serum albumin and annexin A1 may be applicable as potential tear markers of the ophthalmic complication. The biochemical changes in the tear film included the rapid decrease in total antioxidant activity and activity of superoxide dismutase, as well as the decrease in interleukin-4 and the increase in interleukin-6 content thus indicating development of oxidative and pro-inflammatory responses. These findings suggest that antioxidant and anti-inflammatory therapy is a prospective approach for prevention/treatment of perioperative corneal abrasions. The observed anesthesia-induced effects should be taken into consideration in any study of ocular surface diseases employing anesthetized animals.
作者简介
E. Zernii
Belozersky Institute of Physico-Chemical Biology
编辑信件的主要联系方式.
Email: zerni@belozersky.msu.ru
俄罗斯联邦, Leninskye gory bld. 1-40, Moscow, 119992
O. Gancharova
Belozersky Institute of Physico-Chemical Biology
Email: senin@belozersky.msu.ru
俄罗斯联邦, Leninskye gory bld. 1-40, Moscow, 119992
I. Ishutina
Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
Email: senin@belozersky.msu.ru
俄罗斯联邦, ul. Akademika Skryabina 23, Moscow, 109472
V. Baksheeva
Belozersky Institute of Physico-Chemical Biology
Email: senin@belozersky.msu.ru
俄罗斯联邦, Leninskye gory bld. 1-40, Moscow, 119992
M. Golovastova
Belozersky Institute of Physico-Chemical Biology
Email: senin@belozersky.msu.ru
俄罗斯联邦, Leninskye gory bld. 1-40, Moscow, 119992
E. Kabanova
Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
Email: senin@belozersky.msu.ru
俄罗斯联邦, ul. Akademika Skryabina 23, Moscow, 109472
M. Savchenko
Belozersky Institute of Physico-Chemical Biology
Email: senin@belozersky.msu.ru
俄罗斯联邦, Leninskye gory bld. 1-40, Moscow, 119992
M. Serebryakova
Belozersky Institute of Physico-Chemical Biology
Email: senin@belozersky.msu.ru
俄罗斯联邦, Leninskye gory bld. 1-40, Moscow, 119992
L. Sotnikova
Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
Email: senin@belozersky.msu.ru
俄罗斯联邦, ul. Akademika Skryabina 23, Moscow, 109472
A. Zamyatnin
Belozersky Institute of Physico-Chemical Biology; Institute of Molecular Medicine
Email: senin@belozersky.msu.ru
俄罗斯联邦, Leninskye gory bld. 1-40, Moscow, 119992; ul. Trubetskaya 8, Moscow, 119991
P. Philippov
Belozersky Institute of Physico-Chemical Biology
Email: senin@belozersky.msu.ru
俄罗斯联邦, Leninskye gory bld. 1-40, Moscow, 119992
I. Senin
Belozersky Institute of Physico-Chemical Biology
编辑信件的主要联系方式.
Email: senin@belozersky.msu.ru
俄罗斯联邦, Leninskye gory bld. 1-40, Moscow, 119992
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