电邮这篇文章 Metagenomic analysis of taxonomic and functional changes in gut microbiota of patients with the alcohol dependence syndrome
- 作者: Dubinkina V.B.1, Tyakht A.V.1,2, Ilina E.N.2, Ischenko D.S.1,2, Kovarsky B.A.2, Yarygin K.S.1, Pavlenko A.V.1,2, Popenko A.S.2, Alexeev D.G.1,2, Taraskina A.E.3, Nasyrova R.F.3, Krupitski E.M.3, Skorodumova L.O.2, Larin A.K.2, Kostryukova E.S.1,2, Govorun V.M.1,2
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隶属关系:
- Moscow Institute of Physics and Technology (State University)
- Department of Molecular Biology and Genetics
- Saint-Petersburg Bekhterev Psychoneurological Research Institute
- 期: 卷 10, 编号 2 (2016)
- 页面: 184-190
- 栏目: Article
- URL: https://journals.rcsi.science/1990-7508/article/view/197276
- DOI: https://doi.org/10.1134/S1990750816020037
- ID: 197276
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详细
The first metagenomic study of gut microbiota in patients with the alcohol dependence syndrome (ADS) has been performed in the whole-genome sequencing (“shotgun”) format. Taxonomic analysis revealed changes in the relative abundance of the predominant bacteria associated with inflammatioln (including increased levels of Ruminococcus gnavus and R. torques, and decreased levels of Faecalibacterium and Akkermansia genera). The microbiota of ADS patients was characterized by the presence of opportunistic pathogens rarely detected in metagenomes of healthy individuals from different countries. Comparative analysis of total metabolic potential revealed increased relative abundance of KEGG pathways associated with the response to oxidative stress. ADS patients also had increased levels of two specific groups of genes encoding enzymes involved in the metabolism of alcohol, as well as virulence factors. It is possible that gut microbiota of ADS patients demonstrating changes in both taxonomic and functional composition plays a role in modulating the effects of alcohol on the host body
作者简介
V. Dubinkina
Moscow Institute of Physics and Technology (State University)
编辑信件的主要联系方式.
Email: dubinkina@phystech.edu
俄罗斯联邦, Institutskii per. 9, Dolgoprudny, Moscow region, 141700
A. Tyakht
Moscow Institute of Physics and Technology (State University); Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
俄罗斯联邦, Institutskii per. 9, Dolgoprudny, Moscow region, 141700; ul. Malaya Pirogovskaya 1a, Moscow, 119435
E. Ilina
Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
俄罗斯联邦, ul. Malaya Pirogovskaya 1a, Moscow, 119435
D. Ischenko
Moscow Institute of Physics and Technology (State University); Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
俄罗斯联邦, Institutskii per. 9, Dolgoprudny, Moscow region, 141700; ul. Malaya Pirogovskaya 1a, Moscow, 119435
B. Kovarsky
Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
俄罗斯联邦, ul. Malaya Pirogovskaya 1a, Moscow, 119435
K. Yarygin
Moscow Institute of Physics and Technology (State University)
Email: dubinkina@phystech.edu
俄罗斯联邦, Institutskii per. 9, Dolgoprudny, Moscow region, 141700
A. Pavlenko
Moscow Institute of Physics and Technology (State University); Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
俄罗斯联邦, Institutskii per. 9, Dolgoprudny, Moscow region, 141700; ul. Malaya Pirogovskaya 1a, Moscow, 119435
A. Popenko
Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
俄罗斯联邦, ul. Malaya Pirogovskaya 1a, Moscow, 119435
D. Alexeev
Moscow Institute of Physics and Technology (State University); Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
俄罗斯联邦, Institutskii per. 9, Dolgoprudny, Moscow region, 141700; ul. Malaya Pirogovskaya 1a, Moscow, 119435
A. Taraskina
Saint-Petersburg Bekhterev Psychoneurological Research Institute
Email: dubinkina@phystech.edu
俄罗斯联邦, ul. Bekhtereva 3, Saint-Petersburg, 192019
R. Nasyrova
Saint-Petersburg Bekhterev Psychoneurological Research Institute
Email: dubinkina@phystech.edu
俄罗斯联邦, ul. Bekhtereva 3, Saint-Petersburg, 192019
E. Krupitski
Saint-Petersburg Bekhterev Psychoneurological Research Institute
Email: dubinkina@phystech.edu
俄罗斯联邦, ul. Bekhtereva 3, Saint-Petersburg, 192019
L. Skorodumova
Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
俄罗斯联邦, ul. Malaya Pirogovskaya 1a, Moscow, 119435
A. Larin
Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
俄罗斯联邦, ul. Malaya Pirogovskaya 1a, Moscow, 119435
E. Kostryukova
Moscow Institute of Physics and Technology (State University); Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
俄罗斯联邦, Institutskii per. 9, Dolgoprudny, Moscow region, 141700; ul. Malaya Pirogovskaya 1a, Moscow, 119435
V. Govorun
Moscow Institute of Physics and Technology (State University); Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
俄罗斯联邦, Institutskii per. 9, Dolgoprudny, Moscow region, 141700; ul. Malaya Pirogovskaya 1a, Moscow, 119435
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