Мақаланы E-mail арқылы жіберу Metagenomic analysis of taxonomic and functional changes in gut microbiota of patients with the alcohol dependence syndrome
- Авторлар: Dubinkina V.B.1, Tyakht A.V.1,2, Ilina E.N.2, Ischenko D.S.1,2, Kovarsky B.A.2, Yarygin K.S.1, Pavlenko A.V.1,2, Popenko A.S.2, Alexeev D.G.1,2, Taraskina A.E.3, Nasyrova R.F.3, Krupitski E.M.3, Skorodumova L.O.2, Larin A.K.2, Kostryukova E.S.1,2, Govorun V.M.1,2
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Мекемелер:
- Moscow Institute of Physics and Technology (State University)
- Department of Molecular Biology and Genetics
- Saint-Petersburg Bekhterev Psychoneurological Research Institute
- Шығарылым: Том 10, № 2 (2016)
- Беттер: 184-190
- Бөлім: Article
- URL: https://journals.rcsi.science/1990-7508/article/view/197276
- DOI: https://doi.org/10.1134/S1990750816020037
- ID: 197276
Дәйексөз келтіру
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Рұқсат берілді
Тек жазылушылар үшін
Аннотация
The first metagenomic study of gut microbiota in patients with the alcohol dependence syndrome (ADS) has been performed in the whole-genome sequencing (“shotgun”) format. Taxonomic analysis revealed changes in the relative abundance of the predominant bacteria associated with inflammatioln (including increased levels of Ruminococcus gnavus and R. torques, and decreased levels of Faecalibacterium and Akkermansia genera). The microbiota of ADS patients was characterized by the presence of opportunistic pathogens rarely detected in metagenomes of healthy individuals from different countries. Comparative analysis of total metabolic potential revealed increased relative abundance of KEGG pathways associated with the response to oxidative stress. ADS patients also had increased levels of two specific groups of genes encoding enzymes involved in the metabolism of alcohol, as well as virulence factors. It is possible that gut microbiota of ADS patients demonstrating changes in both taxonomic and functional composition plays a role in modulating the effects of alcohol on the host body
Авторлар туралы
V. Dubinkina
Moscow Institute of Physics and Technology (State University)
Хат алмасуға жауапты Автор.
Email: dubinkina@phystech.edu
Ресей, Institutskii per. 9, Dolgoprudny, Moscow region, 141700
A. Tyakht
Moscow Institute of Physics and Technology (State University); Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
Ресей, Institutskii per. 9, Dolgoprudny, Moscow region, 141700; ul. Malaya Pirogovskaya 1a, Moscow, 119435
E. Ilina
Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
Ресей, ul. Malaya Pirogovskaya 1a, Moscow, 119435
D. Ischenko
Moscow Institute of Physics and Technology (State University); Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
Ресей, Institutskii per. 9, Dolgoprudny, Moscow region, 141700; ul. Malaya Pirogovskaya 1a, Moscow, 119435
B. Kovarsky
Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
Ресей, ul. Malaya Pirogovskaya 1a, Moscow, 119435
K. Yarygin
Moscow Institute of Physics and Technology (State University)
Email: dubinkina@phystech.edu
Ресей, Institutskii per. 9, Dolgoprudny, Moscow region, 141700
A. Pavlenko
Moscow Institute of Physics and Technology (State University); Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
Ресей, Institutskii per. 9, Dolgoprudny, Moscow region, 141700; ul. Malaya Pirogovskaya 1a, Moscow, 119435
A. Popenko
Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
Ресей, ul. Malaya Pirogovskaya 1a, Moscow, 119435
D. Alexeev
Moscow Institute of Physics and Technology (State University); Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
Ресей, Institutskii per. 9, Dolgoprudny, Moscow region, 141700; ul. Malaya Pirogovskaya 1a, Moscow, 119435
A. Taraskina
Saint-Petersburg Bekhterev Psychoneurological Research Institute
Email: dubinkina@phystech.edu
Ресей, ul. Bekhtereva 3, Saint-Petersburg, 192019
R. Nasyrova
Saint-Petersburg Bekhterev Psychoneurological Research Institute
Email: dubinkina@phystech.edu
Ресей, ul. Bekhtereva 3, Saint-Petersburg, 192019
E. Krupitski
Saint-Petersburg Bekhterev Psychoneurological Research Institute
Email: dubinkina@phystech.edu
Ресей, ul. Bekhtereva 3, Saint-Petersburg, 192019
L. Skorodumova
Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
Ресей, ul. Malaya Pirogovskaya 1a, Moscow, 119435
A. Larin
Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
Ресей, ul. Malaya Pirogovskaya 1a, Moscow, 119435
E. Kostryukova
Moscow Institute of Physics and Technology (State University); Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
Ресей, Institutskii per. 9, Dolgoprudny, Moscow region, 141700; ul. Malaya Pirogovskaya 1a, Moscow, 119435
V. Govorun
Moscow Institute of Physics and Technology (State University); Department of Molecular Biology and Genetics
Email: dubinkina@phystech.edu
Ресей, Institutskii per. 9, Dolgoprudny, Moscow region, 141700; ul. Malaya Pirogovskaya 1a, Moscow, 119435
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