Tight junction proteins of cerebral endothelial cells in early postnatal development
- Autores: Kuvacheva N.1, Morgun A.1, Malinovskaya N.1, Gorina Y.1, Khilazheva E.1, Pozhilenkova E.1, Panina Y.1, Boytsova E.1, Ruzaeva V.1, Trufanova L.1, Salmina A.1
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Afiliações:
- Voino-Yasenetsky Krasnoyarsk State Medical University
- Edição: Volume 10, Nº 5 (2016)
- Páginas: 372-377
- Seção: Article
- URL: https://journals.rcsi.science/1990-519X/article/view/212165
- DOI: https://doi.org/10.1134/S1990519X16050084
- ID: 212165
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Resumo
The formation and functional plasticity of the blood–brain barrier are inextricably linked to the molecular events occurring in cerebral neurovascular unit during the embryonic and early postnatal development of the organism. To study the features of the barrier genesis under physiological conditions, as well as after perinatal hypoxia and stress in early life, tight junction proteins of cerebral endothelial cells (the number of JAM-, ZO1-, and CLDN5-positive cells) in rats at the age of 7 (P7), 28 (P28), and 70 (P70) days were investigated. It was found that, under physiological conditions, the number of cells expressing JAM, ZO1, and CLDN5 slightly increase in the period from P7 to P70 in the cortex, hippocampus, and amygdala of the brain. After perinatal hypoxia, the number of cells expressing the proteins of tight junctions (JAM, CLDN5) is significantly increased to the age of P28–P70, while the number of ZO1+ cells in the same period of time is reduced. Early life stress causes an imbalance between the expression of ZO1 and other proteins of tight junctions, but these changes are opposite in direction.
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Sobre autores
N. Kuvacheva
Voino-Yasenetsky Krasnoyarsk State Medical University
Autor responsável pela correspondência
Email: natalya.kuvacheva@gmail.com
Rússia, Krasnoyarsk, 660022
A. Morgun
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: natalya.kuvacheva@gmail.com
Rússia, Krasnoyarsk, 660022
N. Malinovskaya
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: natalya.kuvacheva@gmail.com
Rússia, Krasnoyarsk, 660022
Y. Gorina
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: natalya.kuvacheva@gmail.com
Rússia, Krasnoyarsk, 660022
E. Khilazheva
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: natalya.kuvacheva@gmail.com
Rússia, Krasnoyarsk, 660022
E. Pozhilenkova
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: natalya.kuvacheva@gmail.com
Rússia, Krasnoyarsk, 660022
Y. Panina
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: natalya.kuvacheva@gmail.com
Rússia, Krasnoyarsk, 660022
E. Boytsova
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: natalya.kuvacheva@gmail.com
Rússia, Krasnoyarsk, 660022
V. Ruzaeva
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: natalya.kuvacheva@gmail.com
Rússia, Krasnoyarsk, 660022
L. Trufanova
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: natalya.kuvacheva@gmail.com
Rússia, Krasnoyarsk, 660022
A. Salmina
Voino-Yasenetsky Krasnoyarsk State Medical University
Email: natalya.kuvacheva@gmail.com
Rússia, Krasnoyarsk, 660022